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Multi-panel, on-single-chip memristive biosensing

Multi-panel, on-single-chip memristive biosensing
Multi-panel, on-single-chip memristive biosensing
Memristive biosensors have demonstrated excellent capabilities for ultrasensitive bio-detection. In the present work, memristive biosensing chips are designed, fabricated and implemented in a for the first time presented multi-panel on-chip detection for discrete sensing of a target molecule through separate functionalization of individual devices on the same chip. The biosensing scheme is validated by means of labeled (i.e. fluorescence) and label-free (i.e. electrical) characterization methods. This novel memristive multi-panel sensing paradigm paves the way for fast and ultrasensitive PoC (point-of-care) devices allowing the detection of specific targets in complex matrixes where non-specific molecules are present as well, and opening great potential for the application of memristive phenomena in multiplexed ultrasensitive bio-detection and theranostics.
1530-437X
5769 - 5774
Tzouvadaki, Ioulia
a1025ec1-7606-453d-bc71-1f732a4c1f78
Tuoheti, Abuduwaili
f3d98105-3469-4aa7-9d51-d716683a8028
Lorrain, Severine
d965bcce-d69d-4161-ac3d-1e7abc17764f
Quandroni, Manfredo
abedabe5-51df-496f-a6c6-e196bd84e2fb
Doucey, Marie Agnès
03b94196-bd10-4b32-853b-e6ac44cc065c
de Micheli, Giovanni
23af8e38-a795-4edf-b551-9094fdb781e0
Demarchi, Danilo
83bdc9e9-99a0-46a2-8acc-dbbefba09f2e
Carrara, Sandro
0001b4c5-1f62-4789-b0e9-5a187f58b893
Tzouvadaki, Ioulia
a1025ec1-7606-453d-bc71-1f732a4c1f78
Tuoheti, Abuduwaili
f3d98105-3469-4aa7-9d51-d716683a8028
Lorrain, Severine
d965bcce-d69d-4161-ac3d-1e7abc17764f
Quandroni, Manfredo
abedabe5-51df-496f-a6c6-e196bd84e2fb
Doucey, Marie Agnès
03b94196-bd10-4b32-853b-e6ac44cc065c
de Micheli, Giovanni
23af8e38-a795-4edf-b551-9094fdb781e0
Demarchi, Danilo
83bdc9e9-99a0-46a2-8acc-dbbefba09f2e
Carrara, Sandro
0001b4c5-1f62-4789-b0e9-5a187f58b893

Tzouvadaki, Ioulia, Tuoheti, Abuduwaili, Lorrain, Severine, Quandroni, Manfredo, Doucey, Marie Agnès, de Micheli, Giovanni, Demarchi, Danilo and Carrara, Sandro (2019) Multi-panel, on-single-chip memristive biosensing. IEEE Sensors Journal, 19 (14), 5769 - 5774. (doi:10.1109/JSEN.2019.2904393).

Record type: Article

Abstract

Memristive biosensors have demonstrated excellent capabilities for ultrasensitive bio-detection. In the present work, memristive biosensing chips are designed, fabricated and implemented in a for the first time presented multi-panel on-chip detection for discrete sensing of a target molecule through separate functionalization of individual devices on the same chip. The biosensing scheme is validated by means of labeled (i.e. fluorescence) and label-free (i.e. electrical) characterization methods. This novel memristive multi-panel sensing paradigm paves the way for fast and ultrasensitive PoC (point-of-care) devices allowing the detection of specific targets in complex matrixes where non-specific molecules are present as well, and opening great potential for the application of memristive phenomena in multiplexed ultrasensitive bio-detection and theranostics.

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Multipanel, on-single-chip Memristive Biosensing - Accepted Manuscript
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More information

Accepted/In Press date: 7 March 2019
e-pub ahead of print date: 12 March 2019
Published date: 15 July 2019

Identifiers

Local EPrints ID: 431771
URI: https://eprints.soton.ac.uk/id/eprint/431771
ISSN: 1530-437X
PURE UUID: 09e3e33f-4f1f-4a5e-b357-204f67361706

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Date deposited: 14 Jun 2019 16:30
Last modified: 07 Oct 2019 16:32

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Contributors

Author: Abuduwaili Tuoheti
Author: Severine Lorrain
Author: Manfredo Quandroni
Author: Marie Agnès Doucey
Author: Giovanni de Micheli
Author: Danilo Demarchi
Author: Sandro Carrara

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