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Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic

Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic
Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic

Background: Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a significant health and economic burden worldwide. Why some individuals should continue to suffer remains unclear. Methods: The Wessex Asthma Cohort of Difficult Asthma (WATCH) is an ongoing 'real-life', prospective study of patients in the University Hospital Southampton Foundation Trust (UHSFT) Difficult Asthma service. Research data capture is aligned with the extensive clinical characterisation required of a commissioned National Health Service (NHS) Specialist Centre for Severe Asthma. Data acquisition includes detailed clinical, health and disease-related questionnaires, anthropometry, allergy and lung function testing, radiological imaging (in a small subset) and collection of biological samples (blood, urine and sputum). Prospective data are captured in parallel to clinical follow up appointments, with data entered into a bespoke database. Discussion: The pragmatic ongoing nature of the WATCH study allows comprehensive assessment of the real world clinical spectrum seen in a Specialist Asthma Centre and allows a longitudinal perspective of deeply phenotyped patients. It is anticipated that the WATCH cohort would act as a vehicle for potential collaborative asthma studies and will build upon our understanding of mechanisms underlying difficult asthma.

Asthma, Biobank, Cohort, Difficult Asthma, Longitudinal, Prospective, Severe Asthma
1471-2466
1-11
Azim, Adnan
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Mistry, Heena
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Freeman, Anna
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Barber, Clair
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Newell, Colin
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Gove, Kerry
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Thirlwall, Yvette
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Harvey, Matt
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Bentley, Kimberley
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Knight, Deborah
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Long, Karen
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Mitchell, Frances
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Cheng, Yueqing
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Varkonyi-Sepp, Judit
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Grabau, Wolfgang
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Dennison, Paddy
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Haitchi, Hans Michael
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Arshad, S. Hasan
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Djukanovic, Ratko
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Wilkinson, Tom
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Howarth, Peter
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Kurukulaaratchy, Ramesh J.
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Azim, Adnan
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Mistry, Heena
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Freeman, Anna
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Barber, Clair
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Newell, Colin
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Gove, Kerry
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Thirlwall, Yvette
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Harvey, Matt
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Bentley, Kimberley
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Knight, Deborah
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Long, Karen
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Mitchell, Frances
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Cheng, Yueqing
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Varkonyi-Sepp, Judit
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Grabau, Wolfgang
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Dennison, Paddy
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Haitchi, Hans Michael
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Arshad, S. Hasan
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Djukanovic, Ratko
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Wilkinson, Tom
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Howarth, Peter
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Kurukulaaratchy, Ramesh J.
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Azim, Adnan, Mistry, Heena, Freeman, Anna, Barber, Clair, Newell, Colin, Gove, Kerry, Thirlwall, Yvette, Harvey, Matt, Bentley, Kimberley, Knight, Deborah, Long, Karen, Mitchell, Frances, Cheng, Yueqing, Varkonyi-Sepp, Judit, Grabau, Wolfgang, Dennison, Paddy, Haitchi, Hans Michael, Arshad, S. Hasan, Djukanovic, Ratko, Wilkinson, Tom, Howarth, Peter and Kurukulaaratchy, Ramesh J. (2019) Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic. BMC Pulmonary Medicine, 19 (1), 1-11. (doi:10.1186/s12890-019-0862-2).

Record type: Article

Abstract

Background: Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a significant health and economic burden worldwide. Why some individuals should continue to suffer remains unclear. Methods: The Wessex Asthma Cohort of Difficult Asthma (WATCH) is an ongoing 'real-life', prospective study of patients in the University Hospital Southampton Foundation Trust (UHSFT) Difficult Asthma service. Research data capture is aligned with the extensive clinical characterisation required of a commissioned National Health Service (NHS) Specialist Centre for Severe Asthma. Data acquisition includes detailed clinical, health and disease-related questionnaires, anthropometry, allergy and lung function testing, radiological imaging (in a small subset) and collection of biological samples (blood, urine and sputum). Prospective data are captured in parallel to clinical follow up appointments, with data entered into a bespoke database. Discussion: The pragmatic ongoing nature of the WATCH study allows comprehensive assessment of the real world clinical spectrum seen in a Specialist Asthma Centre and allows a longitudinal perspective of deeply phenotyped patients. It is anticipated that the WATCH cohort would act as a vehicle for potential collaborative asthma studies and will build upon our understanding of mechanisms underlying difficult asthma.

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s12890-019-0862-2 - Version of Record
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Accepted/In Press date: 15 May 2019
Published date: 24 May 2019
Keywords: Asthma, Biobank, Cohort, Difficult Asthma, Longitudinal, Prospective, Severe Asthma

Identifiers

Local EPrints ID: 431787
URI: https://eprints.soton.ac.uk/id/eprint/431787
ISSN: 1471-2466
PURE UUID: c4c96f5f-70e9-4d94-a105-ebd83ba53f42
ORCID for Clair Barber: ORCID iD orcid.org/0000-0001-5335-5129
ORCID for Hans Michael Haitchi: ORCID iD orcid.org/0000-0001-8603-302X
ORCID for Ratko Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

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Date deposited: 17 Jun 2019 16:30
Last modified: 20 Jul 2019 01:27

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Contributors

Author: Adnan Azim
Author: Heena Mistry
Author: Anna Freeman
Author: Clair Barber ORCID iD
Author: Colin Newell
Author: Kerry Gove
Author: Yvette Thirlwall
Author: Matt Harvey
Author: Kimberley Bentley
Author: Deborah Knight
Author: Karen Long
Author: Frances Mitchell
Author: Yueqing Cheng
Author: Judit Varkonyi-Sepp
Author: Wolfgang Grabau
Author: Paddy Dennison
Author: S. Hasan Arshad
Author: Tom Wilkinson
Author: Peter Howarth
Author: Ramesh J. Kurukulaaratchy

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