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Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis

Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis
Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis

Osteoarthritis (OA) is characterized by deterioration of the joints and associated with considerable pain and disability. OA is a chronic disease that requires intervention with both non-pharmacological and pharmacological treatment modalities and, inevitably, disease progression may necessitate successive treatments throughout the course of the disease. There is increasing data on the shortfalls of current pharmacological treatment of OA, and safety concerns associated with analgesic therapy use in OA arising from increasing evidence of gastrointestinal, cardiovascular, hepatic and renal adverse events with paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs). Consequently, symptomatic slow-acting drugs for OA (SYSADOAs) may now be considered as a first-line treatment for knee OA, with a particular emphasis placed on the outstanding benefit: risk ratio of pharmaceutical-grade glucosamine and chondroitin sulfate formulations. In this short communication we review recent publications concerned with the safety of paracetamol, NSAIDs and SYSADOAs. Greater understanding of the benefits and limitations of current medications will lead to better disease management in OA. Furthermore, adherence to guideline recommendations across Europe and internationally, such as those from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), will promote evidence-based medicine and patient-centric care, ultimately leading to greater physician and patient satisfaction.

NSAID, Osteoarthritis, Paracetamol, Safety, SYSADOA
0172-8172
1117-1123
Kucharz, Eugene J.
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Szántó, Sándor
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Ivanova Goycheva, Mariana
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Petronijević, Milan
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Šimnovec, Ksenija
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Domżalski, Marcin
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Gallelli, Luca
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Kamenov, Zdravko
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Konstantynowicz, Jerzy
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Radunović, Goran
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Šteňo, Boris
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Stoilov, Rumen
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Stok, Rasto
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Vrana, Radovan
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Bruyère, Olivier
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Cooper, Cyrus
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Reginster, Jean Yves
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Kucharz, Eugene J.
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Szántó, Sándor
e3651b61-9f31-44a6-b4d0-bdd3e6357625
Ivanova Goycheva, Mariana
b0187095-1b99-4cc1-a1fd-6adc76d339aa
Petronijević, Milan
c0d45c83-fb9e-41d5-94ef-ba0ea0045037
Šimnovec, Ksenija
e9bd18d4-f029-4cb1-baa4-433e20bed901
Domżalski, Marcin
cb5b863d-39b3-45e6-92a1-0e9a98c9db66
Gallelli, Luca
9018e987-e80b-414a-b655-6419c8f15cea
Kamenov, Zdravko
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Konstantynowicz, Jerzy
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Radunović, Goran
3c1c4c79-84bf-45b0-adbe-2b579177b1b7
Šteňo, Boris
df1358a7-af29-44cc-91f3-a8f66157bb95
Stoilov, Rumen
da20bf67-5275-49a6-85de-7f5e148ef7bd
Stok, Rasto
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Vrana, Radovan
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Bruyère, Olivier
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Cooper, Cyrus
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Reginster, Jean Yves
08b05e27-73dd-4ce9-90e5-d64ec922147a

Kucharz, Eugene J., Szántó, Sándor, Ivanova Goycheva, Mariana, Petronijević, Milan, Šimnovec, Ksenija, Domżalski, Marcin, Gallelli, Luca, Kamenov, Zdravko, Konstantynowicz, Jerzy, Radunović, Goran, Šteňo, Boris, Stoilov, Rumen, Stok, Rasto, Vrana, Radovan, Bruyère, Olivier, Cooper, Cyrus and Reginster, Jean Yves (2019) Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis. Rheumatology International, 39 (7), 1117-1123. (doi:10.1007/s00296-019-04332-6).

Record type: Article

Abstract

Osteoarthritis (OA) is characterized by deterioration of the joints and associated with considerable pain and disability. OA is a chronic disease that requires intervention with both non-pharmacological and pharmacological treatment modalities and, inevitably, disease progression may necessitate successive treatments throughout the course of the disease. There is increasing data on the shortfalls of current pharmacological treatment of OA, and safety concerns associated with analgesic therapy use in OA arising from increasing evidence of gastrointestinal, cardiovascular, hepatic and renal adverse events with paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs). Consequently, symptomatic slow-acting drugs for OA (SYSADOAs) may now be considered as a first-line treatment for knee OA, with a particular emphasis placed on the outstanding benefit: risk ratio of pharmaceutical-grade glucosamine and chondroitin sulfate formulations. In this short communication we review recent publications concerned with the safety of paracetamol, NSAIDs and SYSADOAs. Greater understanding of the benefits and limitations of current medications will lead to better disease management in OA. Furthermore, adherence to guideline recommendations across Europe and internationally, such as those from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), will promote evidence-based medicine and patient-centric care, ultimately leading to greater physician and patient satisfaction.

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Accepted/In Press date: 21 May 2019
e-pub ahead of print date: 25 May 2019
Keywords: NSAID, Osteoarthritis, Paracetamol, Safety, SYSADOA

Identifiers

Local EPrints ID: 431792
URI: http://eprints.soton.ac.uk/id/eprint/431792
ISSN: 0172-8172
PURE UUID: abc1ce21-a2dd-465c-a9ff-2cb24a0aedf4
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 17 Jun 2019 16:30
Last modified: 26 Nov 2021 02:39

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Contributors

Author: Eugene J. Kucharz
Author: Sándor Szántó
Author: Mariana Ivanova Goycheva
Author: Milan Petronijević
Author: Ksenija Šimnovec
Author: Marcin Domżalski
Author: Luca Gallelli
Author: Zdravko Kamenov
Author: Jerzy Konstantynowicz
Author: Goran Radunović
Author: Boris Šteňo
Author: Rumen Stoilov
Author: Rasto Stok
Author: Radovan Vrana
Author: Olivier Bruyère
Author: Cyrus Cooper ORCID iD
Author: Jean Yves Reginster

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