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Natural history of radiographic first metatarsophalangeal joint osteoarthritis: a nineteen-year population-based cohort study

Natural history of radiographic first metatarsophalangeal joint osteoarthritis: a nineteen-year population-based cohort study
Natural history of radiographic first metatarsophalangeal joint osteoarthritis: a nineteen-year population-based cohort study
Objective: To assess the long-term prevalence, natural history, progression and incidence of 73 radiographic first metatarsophalangeal joint (1st MTPJ) osteoarthritis (OA).

Methods: A longitudinal, cohort design was used in which radiographic OA at the 1st MTPJ was 75 investigated in participants at year 6 (1995) and year 23 (2013-2015) from the Chingford 1000 76 Women study. Radiographic features of osteophytes (OPs) and/or joint space narrowing (JSN) at the 77 1st MTPJ were scored according to a validated foot atlas. Natural history was determined by the 78 change in prevalence, incidence, progression and worsening of OA in the 1st MTPJ.

Results: Complete case matched foot radiographic data were available for 193 of the women 80 currently enrolled in the study, mean age: 75.7 years (SD: 5.2; range 69-90). At the level of the 1st 81 MTPJ, prevalence of OA at year 6 was 21.76% in the left and 24.35% in the right and at year 23 was 82 23.83% in the left and 32.64% in the right. Over the 19-year period, 13.5% of women developed 83 incident OA in the right 1st MTPJ and 8.3% in the left. Both progression and worsening of OA were 84 more evident for OPs and in the right 1st MTPJs.

Conclusion: In this longest study of the natural history of radiographic 1st MTPJ OA to date, the 86 prevalence and incidence of 1st MTPJ OA increased over a 19-year period. Progression and/or 87 worsening of 1st MTPJ OA over time appears to be driven by OP development rather than JSN 88 suggestive of a biomechanical cause.
0893-7524
1224-1230
Bowen, Catherine
fd85c3c5-96d9-49b8-86c6-caa94e1a222b
Gates, Lucy
bc67b8b8-110b-4358-8e1b-6f1d345bd503
McQueen, Peter
b8ea1be8-def6-42d4-9410-031aa194504e
Daniels, Maxine
47d169c6-6f8e-49a6-8503-5a647e8764aa
Delmestri, Antonella
d6087fde-5a65-41de-9b5e-bcefc4379ceb
Drechsler, Wendy
c0019fb1-fab0-48e1-97bb-635fa4996b08
Stephensen, David
1b335208-1ab1-4fd7-811f-923c7297eeff
Doherty, Michael
ab3e38b1-4e66-48b0-ae34-ec710c4fce2c
Arden, Nigel
23af958d-835c-4d79-be54-4bbe4c68077f
Bowen, Catherine
fd85c3c5-96d9-49b8-86c6-caa94e1a222b
Gates, Lucy
bc67b8b8-110b-4358-8e1b-6f1d345bd503
McQueen, Peter
b8ea1be8-def6-42d4-9410-031aa194504e
Daniels, Maxine
47d169c6-6f8e-49a6-8503-5a647e8764aa
Delmestri, Antonella
d6087fde-5a65-41de-9b5e-bcefc4379ceb
Drechsler, Wendy
c0019fb1-fab0-48e1-97bb-635fa4996b08
Stephensen, David
1b335208-1ab1-4fd7-811f-923c7297eeff
Doherty, Michael
ab3e38b1-4e66-48b0-ae34-ec710c4fce2c
Arden, Nigel
23af958d-835c-4d79-be54-4bbe4c68077f

Bowen, Catherine, Gates, Lucy, McQueen, Peter, Daniels, Maxine, Delmestri, Antonella, Drechsler, Wendy, Stephensen, David, Doherty, Michael and Arden, Nigel (2020) Natural history of radiographic first metatarsophalangeal joint osteoarthritis: a nineteen-year population-based cohort study. Arthritis Care & Research, 72 (9), 1224-1230, [acr.24015]. (doi:10.1002/acr.24015).

Record type: Article

Abstract

Objective: To assess the long-term prevalence, natural history, progression and incidence of 73 radiographic first metatarsophalangeal joint (1st MTPJ) osteoarthritis (OA).

Methods: A longitudinal, cohort design was used in which radiographic OA at the 1st MTPJ was 75 investigated in participants at year 6 (1995) and year 23 (2013-2015) from the Chingford 1000 76 Women study. Radiographic features of osteophytes (OPs) and/or joint space narrowing (JSN) at the 77 1st MTPJ were scored according to a validated foot atlas. Natural history was determined by the 78 change in prevalence, incidence, progression and worsening of OA in the 1st MTPJ.

Results: Complete case matched foot radiographic data were available for 193 of the women 80 currently enrolled in the study, mean age: 75.7 years (SD: 5.2; range 69-90). At the level of the 1st 81 MTPJ, prevalence of OA at year 6 was 21.76% in the left and 24.35% in the right and at year 23 was 82 23.83% in the left and 32.64% in the right. Over the 19-year period, 13.5% of women developed 83 incident OA in the right 1st MTPJ and 8.3% in the left. Both progression and worsening of OA were 84 more evident for OPs and in the right 1st MTPJs.

Conclusion: In this longest study of the natural history of radiographic 1st MTPJ OA to date, the 86 prevalence and incidence of 1st MTPJ OA increased over a 19-year period. Progression and/or 87 worsening of 1st MTPJ OA over time appears to be driven by OP development rather than JSN 88 suggestive of a biomechanical cause.

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The natural history of radiographic first metatarsophalangeal joint osteoarthritis: a nineteen-year population based cohort study - Accepted Manuscript
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Accepted/In Press date: 18 June 2019
e-pub ahead of print date: 31 August 2020
Published date: 31 August 2020

Identifiers

Local EPrints ID: 431908
URI: http://eprints.soton.ac.uk/id/eprint/431908
ISSN: 0893-7524
PURE UUID: f15cf620-102c-4675-bad9-24e20652ebb7
ORCID for Catherine Bowen: ORCID iD orcid.org/0000-0002-7252-9515
ORCID for Lucy Gates: ORCID iD orcid.org/0000-0002-8627-3418

Catalogue record

Date deposited: 21 Jun 2019 16:30
Last modified: 26 Nov 2021 05:52

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Contributors

Author: Catherine Bowen ORCID iD
Author: Lucy Gates ORCID iD
Author: Peter McQueen
Author: Maxine Daniels
Author: Antonella Delmestri
Author: Wendy Drechsler
Author: David Stephensen
Author: Michael Doherty
Author: Nigel Arden

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