A neural lens for super-resolution biological imaging
A neural lens for super-resolution biological imaging
Visualizing structures smaller than the eye can see has been a driving force in scientific research since the invention of the optical microscope. Here, we use a network of neural networks to create a neural lens that has the ability to transform 20× optical microscope images into a resolution comparable to a 1500× scanning electron microscope image. In addition to magnification, the neural lens simultaneously identifies the types of objects present, and hence can label, colour-enhance and remove specific types of objects in the magnified image. The neural lens was used for the imaging of Iva xanthiifolia and Galanthus pollen grains, showing the potential for low cost, non-destructive, high-resolution microscopy with automatic image processing.
Grant-Jacob, James
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MacKay, Benita, Scout
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Xie, Yunhui
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Heath, Daniel J
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Loxham, Matthew
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Eason, Robert
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Mills, Benjamin
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Grant-Jacob, James
c5d144d8-3c43-4195-8e80-edd96bfda91b
MacKay, Benita, Scout
318d298f-5b38-43d7-b30d-8cd07f69acd4
Xie, Yunhui
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Heath, Daniel J
d53c269d-90d2-41e6-aa63-a03f8f014d21
Loxham, Matthew
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Eason, Robert
e38684c3-d18c-41b9-a4aa-def67283b020
Mills, Benjamin
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Grant-Jacob, James, MacKay, Benita, Scout, Xie, Yunhui, Heath, Daniel J, Loxham, Matthew, Eason, Robert and Mills, Benjamin
(2019)
A neural lens for super-resolution biological imaging.
Journal of Physics Communications.
(doi:10.1088/2399-6528/ab267d).
Abstract
Visualizing structures smaller than the eye can see has been a driving force in scientific research since the invention of the optical microscope. Here, we use a network of neural networks to create a neural lens that has the ability to transform 20× optical microscope images into a resolution comparable to a 1500× scanning electron microscope image. In addition to magnification, the neural lens simultaneously identifies the types of objects present, and hence can label, colour-enhance and remove specific types of objects in the magnified image. The neural lens was used for the imaging of Iva xanthiifolia and Galanthus pollen grains, showing the potential for low cost, non-destructive, high-resolution microscopy with automatic image processing.
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A_Neural_Lens_BPEX_Submitted_Final_Black_14052019
- Accepted Manuscript
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Grant-Jacob_2019_J._Phys._Commun._3_065004
- Version of Record
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Accepted/In Press date: 31 May 2019
e-pub ahead of print date: 17 June 2019
Identifiers
Local EPrints ID: 431978
URI: http://eprints.soton.ac.uk/id/eprint/431978
PURE UUID: 2e3eae6f-1e2a-47fd-87c2-a2272232fe8e
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Date deposited: 25 Jun 2019 16:30
Last modified: 16 Mar 2024 04:18
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Contributors
Author:
Benita, Scout MacKay
Author:
Yunhui Xie
Author:
Daniel J Heath
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