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Objective methods to measure vestibular evoked myogenic potential response saccular tuning curves

Objective methods to measure vestibular evoked myogenic potential response saccular tuning curves
Objective methods to measure vestibular evoked myogenic potential response saccular tuning curves

Objective: To detect cervical vestibular evoked myogenic potential (cVEMP) responses using objective statistical approaches and to apply this approach to estimate saccular frequency-tuning curves in volunteers and Ménière’s disease (MD) patients.

Design: Estimates of cVEMP threshold were carried out by 3 expert raters at 500 Hz and compared to objective threshold estimates (using Hotelling’s T2 [HT2] and Fsp ). Saccular tuning curves were objectively estimated.

Study sample: Objective and subjective estimates of cVEMP response thresholds were compared for 13 normal hearing adults. Objective measurement of saccular tuning curves was explored in 20 healthy adults and 15 patients with MD.

Results: Significant variability was seen between subjective estimates of cVEMP thresholds. Objective analysis with the HT2 test was more sensitive than 2 of 3 experts in detecting responses. The measurement time of cVEMP was considerably reduced with the HT2 test. Objective saccular tuning curves in volunteers showed strongest responses at 500 Hz. A flatter tuning curve was seen for MD patients.

Conclusions: There is significant variability in subjective estimations of cVEMP thresholds. Objective analysis methods are more sensitive than subjective analysis, can detect responses rapidly and have potential to reduce variability in threshold estimates, hence they appear well suited to measure cVEMP tuning curves.

cVEMP response detection, Hotelling’s T2, Ménière's disease, Saccular frequency-tuning curves
1499-2027
1-37
Obeidat, Faten Saeed
41a0c78a-59e6-46c7-9a7e-fde736d10b27
Lewis Bell, Steven
91de0801-d2b7-44ba-8e8e-523e672aed8a
Obeidat, Faten Saeed
41a0c78a-59e6-46c7-9a7e-fde736d10b27
Lewis Bell, Steven
91de0801-d2b7-44ba-8e8e-523e672aed8a

Obeidat, Faten Saeed and Lewis Bell, Steven (2019) Objective methods to measure vestibular evoked myogenic potential response saccular tuning curves. International Journal of Audiology, 1-37. (doi:10.1080/14992027.2019.1613574).

Record type: Article

Abstract

Objective: To detect cervical vestibular evoked myogenic potential (cVEMP) responses using objective statistical approaches and to apply this approach to estimate saccular frequency-tuning curves in volunteers and Ménière’s disease (MD) patients.

Design: Estimates of cVEMP threshold were carried out by 3 expert raters at 500 Hz and compared to objective threshold estimates (using Hotelling’s T2 [HT2] and Fsp ). Saccular tuning curves were objectively estimated.

Study sample: Objective and subjective estimates of cVEMP response thresholds were compared for 13 normal hearing adults. Objective measurement of saccular tuning curves was explored in 20 healthy adults and 15 patients with MD.

Results: Significant variability was seen between subjective estimates of cVEMP thresholds. Objective analysis with the HT2 test was more sensitive than 2 of 3 experts in detecting responses. The measurement time of cVEMP was considerably reduced with the HT2 test. Objective saccular tuning curves in volunteers showed strongest responses at 500 Hz. A flatter tuning curve was seen for MD patients.

Conclusions: There is significant variability in subjective estimations of cVEMP thresholds. Objective analysis methods are more sensitive than subjective analysis, can detect responses rapidly and have potential to reduce variability in threshold estimates, hence they appear well suited to measure cVEMP tuning curves.

Text
Obeidat Bell 2018 A - Accepted Manuscript
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 23 April 2019
e-pub ahead of print date: 13 May 2019
Keywords: cVEMP response detection, Hotelling’s T2, Ménière's disease, Saccular frequency-tuning curves

Identifiers

Local EPrints ID: 432091
URI: http://eprints.soton.ac.uk/id/eprint/432091
ISSN: 1499-2027
PURE UUID: d44e40e9-6306-4b4f-a70d-2fe162fc1860

Catalogue record

Date deposited: 01 Jul 2019 16:30
Last modified: 25 Nov 2021 16:58

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Contributors

Author: Faten Saeed Obeidat

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