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Growth pattern of infants with gastroschisis in the neonatal period

Growth pattern of infants with gastroschisis in the neonatal period
Growth pattern of infants with gastroschisis in the neonatal period

Background/Aim: Early postnatal growth patterns may have significant long term health effects. Although preterm infants on parenteral nutrition (PN)exhibit poor growth, growth pattern of term or near-term infants requiring PN is not well reported. We aimed to investigate this in infants born with gastroschisis. Methods: Retrospective review of all infants with gastroschisis requiring PN treated at a single centre over a 4 year period. Growth and clinical data were retrieved, and weight SDS scores for corrected gestational age calculated. Weight SDS (mean ± SD)were compared at clinically relevant timepoints and multi-level regression used to model growth trends over time. Main results: During the study period 61 infants with gastroschisis were treated; all were included. Infants were small for gestational age at birth for weight (SDS score −0.87 ± 0.85). Weight SDS decreased significantly during the first 10 days of age (mean decrease 0.81 ± 0.56; p < 0.0001)and between birth and discharge (mean decrease 0.81 ± 0.56; p < 0.0001). Despite tolerating full enteral feeds, weight SDS velocity was negative around the time of transition from parenteral to enteral feed. There was evidence of ‘catch up’ growth between 3 and 6 months of age. Conclusion: Despite nutritional support with PN, infants with gastroschisis demonstrate significant growth failure during the newborn period. Further efforts are required to understand the underlying mechanisms, improve nutritional support and to evaluate the long term consequences of postnatal growth failure in this population.

2405-4577
82-87
Hall, Nigel J.
6919e8af-3890-42c1-98a7-c110791957cf
Drewett, Melanie
017b4e4c-3143-40bf-bd6b-a36a8df51f3e
Burge, David M.
587fc481-8d2f-4801-94dd-f03ac4410f41
Eaton, Simon
e14103c2-c06a-45e6-87fe-2358a3371283
Hall, Nigel J.
6919e8af-3890-42c1-98a7-c110791957cf
Drewett, Melanie
017b4e4c-3143-40bf-bd6b-a36a8df51f3e
Burge, David M.
587fc481-8d2f-4801-94dd-f03ac4410f41
Eaton, Simon
e14103c2-c06a-45e6-87fe-2358a3371283

Hall, Nigel J., Drewett, Melanie, Burge, David M. and Eaton, Simon (2019) Growth pattern of infants with gastroschisis in the neonatal period. Clinical Nutrition ESPEN, 32, 82-87. (doi:10.1016/j.clnesp.2019.04.008).

Record type: Article

Abstract

Background/Aim: Early postnatal growth patterns may have significant long term health effects. Although preterm infants on parenteral nutrition (PN)exhibit poor growth, growth pattern of term or near-term infants requiring PN is not well reported. We aimed to investigate this in infants born with gastroschisis. Methods: Retrospective review of all infants with gastroschisis requiring PN treated at a single centre over a 4 year period. Growth and clinical data were retrieved, and weight SDS scores for corrected gestational age calculated. Weight SDS (mean ± SD)were compared at clinically relevant timepoints and multi-level regression used to model growth trends over time. Main results: During the study period 61 infants with gastroschisis were treated; all were included. Infants were small for gestational age at birth for weight (SDS score −0.87 ± 0.85). Weight SDS decreased significantly during the first 10 days of age (mean decrease 0.81 ± 0.56; p < 0.0001)and between birth and discharge (mean decrease 0.81 ± 0.56; p < 0.0001). Despite tolerating full enteral feeds, weight SDS velocity was negative around the time of transition from parenteral to enteral feed. There was evidence of ‘catch up’ growth between 3 and 6 months of age. Conclusion: Despite nutritional support with PN, infants with gastroschisis demonstrate significant growth failure during the newborn period. Further efforts are required to understand the underlying mechanisms, improve nutritional support and to evaluate the long term consequences of postnatal growth failure in this population.

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Accepted/In Press date: 25 April 2019
e-pub ahead of print date: 29 May 2019

Identifiers

Local EPrints ID: 432194
URI: http://eprints.soton.ac.uk/id/eprint/432194
ISSN: 2405-4577
PURE UUID: ce357db8-5e97-4f51-9cfb-698c562da9bb
ORCID for Nigel J. Hall: ORCID iD orcid.org/0000-0001-8570-9374

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Date deposited: 03 Jul 2019 16:30
Last modified: 16 Mar 2024 07:56

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Author: Nigel J. Hall ORCID iD
Author: Melanie Drewett
Author: David M. Burge
Author: Simon Eaton

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