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Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor

Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor
Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor
Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels.
wearable, sensors
2041-1723
Nightingale, Adrian
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Leong, Chi Leng
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Burnish, Rachel
a719a04e-b8ee-472b-ac06-91f4a2b28589
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Zhang, Yu
9b5536fe-d7c1-40a1-b3f5-c0cc6f0724e7
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494
Boutelle, Martyn G.
71e1592c-2e38-4695-8104-b233cc615494
Voegeli, David
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
Nightingale, Adrian
4b51311d-c6c3-40d5-a13f-ab8917031ab3
Leong, Chi Leng
2e4c1b7f-b864-439a-acb8-4ec81ee54eea
Burnish, Rachel
a719a04e-b8ee-472b-ac06-91f4a2b28589
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Zhang, Yu
9b5536fe-d7c1-40a1-b3f5-c0cc6f0724e7
Clough, Geraldine
9f19639e-a929-4976-ac35-259f9011c494
Boutelle, Martyn G.
71e1592c-2e38-4695-8104-b233cc615494
Voegeli, David
e6f5d112-55b0-40c1-a6ad-8929a2d84a10
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa

Nightingale, Adrian, Leong, Chi Leng, Burnish, Rachel, Hassan, Sammer-Ul, Zhang, Yu, Clough, Geraldine, Boutelle, Martyn G., Voegeli, David and Niu, Xize (2019) Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor. Nature Communications, 10, [2741]. (doi:10.1038/s41467-019-10401-y).

Record type: Article

Abstract

Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels.

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s41467-019-10401-y - Version of Record
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 7 May 2019
e-pub ahead of print date: 21 June 2019
Published date: 21 June 2019
Keywords: wearable, sensors

Identifiers

Local EPrints ID: 432230
URI: http://eprints.soton.ac.uk/id/eprint/432230
ISSN: 2041-1723
PURE UUID: 68d4ec42-356c-4d0e-89b3-f3b58d90e9fb
ORCID for Sammer-Ul Hassan: ORCID iD orcid.org/0000-0002-0319-5814
ORCID for Geraldine Clough: ORCID iD orcid.org/0000-0002-6226-8964
ORCID for David Voegeli: ORCID iD orcid.org/0000-0003-3457-7177

Catalogue record

Date deposited: 04 Jul 2019 16:30
Last modified: 26 Nov 2021 02:39

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Contributors

Author: Chi Leng Leong
Author: Rachel Burnish
Author: Yu Zhang
Author: Martyn G. Boutelle
Author: David Voegeli ORCID iD
Author: Xize Niu

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