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Using systematic literature reviews to develop guidelines for the management of inflammatory arthritis

Using systematic literature reviews to develop guidelines for the management of inflammatory arthritis
Using systematic literature reviews to develop guidelines for the management of inflammatory arthritis
The vast amount of research published on clinical areas can make awareness of current data difficult. Systematic literature reviews (SLR) are performed in order to identify, appraise and summarise the available evidence relating to specific clinical questions, and form the basis of the process used to produce clinical guidelines.

This thesis describes the different processes used to produce guidelines using SLR. It includes a review of the literature on imaging in the management of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) as examples.

To perform the RA review, key clinical questions were generated on the role of imaging in RA, which included the use of conventional radiography (CR),ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT),dual-emission X-ray absorptiometry (DXA), digital X-ray radiogrammetry (DXR), scintigraphy and positron emission tomography (PET). A comprehensive SLR was then performed resulting in recommendations on the role of imaging in making a diagnosis of RA, detecting inflammation and damage, predicting outcome and response to treatment, monitoring disease activity, progression and remission. A similar process was used to produce recommendations in the management of JIA;however the lack of quality data meant that ‘points to consider’ were created.

The thesis also considers the quality of existing recommendations with potential areas for improvement discussed. It concludes with a discussion of the overall benefit of guidelines.
University of Southampton
Bourn, Alexandra
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Bourn, Alexandra
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Edwards, Christopher
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Cooper, Cyrus
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Arden, Nigel
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Bourn, Alexandra (2018) Using systematic literature reviews to develop guidelines for the management of inflammatory arthritis. University of Southampton, Doctoral Thesis, 295pp.

Record type: Thesis (Doctoral)

Abstract

The vast amount of research published on clinical areas can make awareness of current data difficult. Systematic literature reviews (SLR) are performed in order to identify, appraise and summarise the available evidence relating to specific clinical questions, and form the basis of the process used to produce clinical guidelines.

This thesis describes the different processes used to produce guidelines using SLR. It includes a review of the literature on imaging in the management of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) as examples.

To perform the RA review, key clinical questions were generated on the role of imaging in RA, which included the use of conventional radiography (CR),ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT),dual-emission X-ray absorptiometry (DXA), digital X-ray radiogrammetry (DXR), scintigraphy and positron emission tomography (PET). A comprehensive SLR was then performed resulting in recommendations on the role of imaging in making a diagnosis of RA, detecting inflammation and damage, predicting outcome and response to treatment, monitoring disease activity, progression and remission. A similar process was used to produce recommendations in the management of JIA;however the lack of quality data meant that ‘points to consider’ were created.

The thesis also considers the quality of existing recommendations with potential areas for improvement discussed. It concludes with a discussion of the overall benefit of guidelines.

Text
Bourn MD thesis October 2018 - Version of Record
Available under License University of Southampton Thesis Licence.
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Published date: October 2018

Identifiers

Local EPrints ID: 432266
URI: http://eprints.soton.ac.uk/id/eprint/432266
PURE UUID: 45007775-b9ae-43b6-90e5-77f63164fde4
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 05 Jul 2019 16:30
Last modified: 31 Aug 2019 00:38

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Contributors

Author: Alexandra Bourn
Thesis advisor: Christopher Edwards
Thesis advisor: Cyrus Cooper ORCID iD
Thesis advisor: Nigel Arden

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