Double-hit lymphoma: So what?
Double-hit lymphoma: So what?
The revised WHO classification moved all aggressive B-cell lymphomas with a MYC translocation and a concurrent translocation of BCL2 and/or BCL6 into a single diagnostic category. These are the double- and triple-hit lymphomas. These represent a group with typically a poor outcome to conventional therapy, and as a result, intensification of immunochemotherapy has been explored. The optimal approach is far from clear, and recent insight into the biology suggest that they may represent just a subgroup of molecular high-grade B-cell lymphomas that maybe identified by gene expression profiling. There are a number of novel therapeutic approaches under investigation.
19-23
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
June 2019
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Davies, Andrew
(2019)
Double-hit lymphoma: So what?
Hematological Oncology, 37 (S1), .
(doi:10.1002/hon.2581).
Abstract
The revised WHO classification moved all aggressive B-cell lymphomas with a MYC translocation and a concurrent translocation of BCL2 and/or BCL6 into a single diagnostic category. These are the double- and triple-hit lymphomas. These represent a group with typically a poor outcome to conventional therapy, and as a result, intensification of immunochemotherapy has been explored. The optimal approach is far from clear, and recent insight into the biology suggest that they may represent just a subgroup of molecular high-grade B-cell lymphomas that maybe identified by gene expression profiling. There are a number of novel therapeutic approaches under investigation.
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e-pub ahead of print date: 12 June 2019
Published date: June 2019
Additional Information:
Supplement: 15th International Conference on Malignant Lymphoma, Palazzo dei Congressi, Lugano, Switzerland, 18‐22 June, 2019
Identifiers
Local EPrints ID: 432315
URI: http://eprints.soton.ac.uk/id/eprint/432315
ISSN: 0278-0232
PURE UUID: 02672d51-ccb8-495a-8a36-3b91467ef7c7
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Date deposited: 09 Jul 2019 16:30
Last modified: 16 Mar 2024 03:58
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