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The nonpathogenic commensal Neisseria: friends and foes in infectious disease

The nonpathogenic commensal Neisseria: friends and foes in infectious disease
The nonpathogenic commensal Neisseria: friends and foes in infectious disease
Purpose of review: non-pathogenic commensal Neisseria are rarely considered in the clinical setting despite evidence that they can cause invasive opportunistic infections. In contrast, they may offer protection against pathogenic Neisseria, and such relationships are being actively explored in experimental studies.

Recent findings: recent case reports are presented of invasive infection caused by non-pathogenic Neisseria in patients on novel biologic therapies. On the other hand, Neisseria lactamica, a non-pathogenic commensal, has been shown in human challenge studies to inhibit colonisation by Neisseria meningitidis. Experimental mouse models have also explored the inhibitory effects of non-pathogenic Neisseria on Neisseria gonnhoreae infection. Cutting-edge advances in metagenomics and microbiomics are being used to understand the mechanisms underpinning these effects.

Summary: clinicians should have increased awareness of non pathogenic Neisseria. Firstly, as new immunomodulating therapies become licenced, the interactions that maintain balance between commensals and their human hosts may be altered. Secondly, these bacteria are showing promise in their capacity to exclude pathogenic Neisseria species from their anatomical niches.
human challenge, invasive infection, metagenomics, Neisseria, nonpathogenic
0951-7375
490-496
Dorey, Robert B.
8d4b042f-1659-4e76-99c2-23cde78ca4f5
Theodosiou, Anastasia A.
12be2a94-90a5-47da-beba-bd7c5e99de94
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Jones, Christine E.
2ca17135-08f9-4d30-b295-c33b3660e2ec
Dorey, Robert B.
8d4b042f-1659-4e76-99c2-23cde78ca4f5
Theodosiou, Anastasia A.
12be2a94-90a5-47da-beba-bd7c5e99de94
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Jones, Christine E.
2ca17135-08f9-4d30-b295-c33b3660e2ec

Dorey, Robert B., Theodosiou, Anastasia A., Read, Robert C. and Jones, Christine E. (2019) The nonpathogenic commensal Neisseria: friends and foes in infectious disease. Current Opinion in Infectious Diseases, 32 (5), 490-496. (doi:10.1097/QCO.0000000000000585).

Record type: Article

Abstract

Purpose of review: non-pathogenic commensal Neisseria are rarely considered in the clinical setting despite evidence that they can cause invasive opportunistic infections. In contrast, they may offer protection against pathogenic Neisseria, and such relationships are being actively explored in experimental studies.

Recent findings: recent case reports are presented of invasive infection caused by non-pathogenic Neisseria in patients on novel biologic therapies. On the other hand, Neisseria lactamica, a non-pathogenic commensal, has been shown in human challenge studies to inhibit colonisation by Neisseria meningitidis. Experimental mouse models have also explored the inhibitory effects of non-pathogenic Neisseria on Neisseria gonnhoreae infection. Cutting-edge advances in metagenomics and microbiomics are being used to understand the mechanisms underpinning these effects.

Summary: clinicians should have increased awareness of non pathogenic Neisseria. Firstly, as new immunomodulating therapies become licenced, the interactions that maintain balance between commensals and their human hosts may be altered. Secondly, these bacteria are showing promise in their capacity to exclude pathogenic Neisseria species from their anatomical niches.

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Manuscript Non-pathogenic commensal Neisseria 190702 - Accepted Manuscript
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Figure one Non-pathogenic commensal Neisseria 190519
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Accepted/In Press date: 1 July 2019
e-pub ahead of print date: 1 October 2019
Published date: 1 October 2019
Keywords: human challenge, invasive infection, metagenomics, Neisseria, nonpathogenic

Identifiers

Local EPrints ID: 432359
URI: http://eprints.soton.ac.uk/id/eprint/432359
ISSN: 0951-7375
PURE UUID: be727c88-024e-42a5-bac4-c1624a9de767
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

Catalogue record

Date deposited: 11 Jul 2019 16:30
Last modified: 18 Feb 2021 17:18

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