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Activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease

Activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease
Activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the resolution of inflammation is contained in time and space enabling the restoration of tissue homeostasis. There is increasing evidence that poor and/or inappropriate resolution of inflammation participates in the pathogenesis of chronic inflammatory diseases, extending in time the actions of pro-inflammatory mechanisms, and responsible in the long run for excessive tissue damage and pathology. In this review, we will focus on how resolution can be the target for therapy in “Th1/Th17 cell-driven” immune diseases and “Th2 cell-driven” immune diseases, with inflammatory bowel diseases (IBD) and asthma, as relevant examples. We describe the main cells and mediators stimulating the resolution of inflammation and discuss how pharmacological and dietary interventions but also life style factors, physical and psychological conditions, might influence the resolution phase. A better understanding of the impact of endogenous and exogenous factors on the resolution of inflammation might open a whole area in the development of personalized therapies in non-resolving chronic inflammatory diseases.
1664-3224
1-19
Barnig, Cindy
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Bezema, Tjitske
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Calder, Philip
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Charloux, Anne
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Frossard, Nelly
a6be4794-ab28-4f94-ac24-c995dd90c564
Garssen, Johan
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Haworth, Oliver
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Dilevskaya, Ksenia
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Levi-Schaffer, Francesca
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Lonsdorfer, Evelyne
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Wauben, Marca
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Kraneveld, Aletta D.
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te Velde, Anje A.
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Barnig, Cindy
b1d3b490-dab3-4262-a4b3-6337c28ab333
Bezema, Tjitske
fc4fab0e-a406-4a9e-97d1-27545a879f9b
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Charloux, Anne
8a318888-8af4-4b13-9252-8d2b338e6a62
Frossard, Nelly
a6be4794-ab28-4f94-ac24-c995dd90c564
Garssen, Johan
6b588ae2-97ce-4805-aca5-eb7034b1460e
Haworth, Oliver
0ac87603-8abe-428a-84dc-b01c89b31ac7
Dilevskaya, Ksenia
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Levi-Schaffer, Francesca
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Lonsdorfer, Evelyne
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Wauben, Marca
b07d3b74-6eea-4f4b-9521-da076c1b257b
Kraneveld, Aletta D.
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te Velde, Anje A.
989a499b-dc1c-4c87-ada4-d7f2dca03b15

Barnig, Cindy, Bezema, Tjitske, Calder, Philip, Charloux, Anne, Frossard, Nelly, Garssen, Johan, Haworth, Oliver, Dilevskaya, Ksenia, Levi-Schaffer, Francesca, Lonsdorfer, Evelyne, Wauben, Marca, Kraneveld, Aletta D. and te Velde, Anje A. (2019) Activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease. Frontiers in Immunology, 10, 1-19, [1699]. (doi:10.3389/fimmu.2019.01699).

Record type: Article

Abstract

Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the resolution of inflammation is contained in time and space enabling the restoration of tissue homeostasis. There is increasing evidence that poor and/or inappropriate resolution of inflammation participates in the pathogenesis of chronic inflammatory diseases, extending in time the actions of pro-inflammatory mechanisms, and responsible in the long run for excessive tissue damage and pathology. In this review, we will focus on how resolution can be the target for therapy in “Th1/Th17 cell-driven” immune diseases and “Th2 cell-driven” immune diseases, with inflammatory bowel diseases (IBD) and asthma, as relevant examples. We describe the main cells and mediators stimulating the resolution of inflammation and discuss how pharmacological and dietary interventions but also life style factors, physical and psychological conditions, might influence the resolution phase. A better understanding of the impact of endogenous and exogenous factors on the resolution of inflammation might open a whole area in the development of personalized therapies in non-resolving chronic inflammatory diseases.

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Accepted/In Press date: 8 July 2019
Published date: 23 July 2019

Identifiers

Local EPrints ID: 432384
URI: http://eprints.soton.ac.uk/id/eprint/432384
ISSN: 1664-3224
PURE UUID: fc2a64a9-34c1-419f-8cd0-b15df6099711
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

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Date deposited: 12 Jul 2019 16:30
Last modified: 22 Nov 2021 07:30

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Contributors

Author: Cindy Barnig
Author: Tjitske Bezema
Author: Philip Calder ORCID iD
Author: Anne Charloux
Author: Nelly Frossard
Author: Johan Garssen
Author: Oliver Haworth
Author: Ksenia Dilevskaya
Author: Francesca Levi-Schaffer
Author: Evelyne Lonsdorfer
Author: Marca Wauben
Author: Aletta D. Kraneveld
Author: Anje A. te Velde

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