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FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression

FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression
FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression
Protein Arginine Methyl Transferase 1 (PRMT1) is deemed to be a potential oncogenic protein considering its overexpression in several malignancies including colorectal cancer. However, the molecular pathogenesis regarding PRMT1 overexpression and overall poor patient survival involved in this devastating and life threatening cancer remains obscured. In our previous study, we have identified FAM98A as a novel substrate of PRMT1 and also identified its role in ovarian cancer progression. Here, we showed that the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression. Analysis of the data from The Cancer Genome Atlas (TCGA) database and clinical colorectal cancer specimens also demonstrated a strong positive correlation and co-occurrence of PRMT1, FAM98A and FAM98B. These findings provide a mechanistic insight into how knockdown of FAM98A or FAM98B can suppress the malignant characteristics of cancer cells. Besides, we showed that FAM98A and FAM98B are working in the same axis as knockdown of both proteins together does not cause additional reduction in the cellular proliferation and colony formation of colorectal cancer cells.
1099-0461
1-13
Akter, Khondker Ayesha
158fdaf8-1b26-4513-b123-f0e1729578b0
Mansour, Mohammed
03d901e1-959e-4c7d-acc6-33c6a4b129f7
Hyodo, Toshinori
d7721c0c-bfff-4899-b244-2686bfadd145
Senga, Takeshi
3d9abecc-8bf9-4c1c-a64a-f598d5767cfc
Akter, Khondker Ayesha
158fdaf8-1b26-4513-b123-f0e1729578b0
Mansour, Mohammed
03d901e1-959e-4c7d-acc6-33c6a4b129f7
Hyodo, Toshinori
d7721c0c-bfff-4899-b244-2686bfadd145
Senga, Takeshi
3d9abecc-8bf9-4c1c-a64a-f598d5767cfc

Akter, Khondker Ayesha, Mansour, Mohammed, Hyodo, Toshinori and Senga, Takeshi (2017) FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. Journal of Biochemical and Molecular Toxicology, 84, 1-13. (doi:10.1016/j.biocel.2016.12.013).

Record type: Article

Abstract

Protein Arginine Methyl Transferase 1 (PRMT1) is deemed to be a potential oncogenic protein considering its overexpression in several malignancies including colorectal cancer. However, the molecular pathogenesis regarding PRMT1 overexpression and overall poor patient survival involved in this devastating and life threatening cancer remains obscured. In our previous study, we have identified FAM98A as a novel substrate of PRMT1 and also identified its role in ovarian cancer progression. Here, we showed that the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression. Analysis of the data from The Cancer Genome Atlas (TCGA) database and clinical colorectal cancer specimens also demonstrated a strong positive correlation and co-occurrence of PRMT1, FAM98A and FAM98B. These findings provide a mechanistic insight into how knockdown of FAM98A or FAM98B can suppress the malignant characteristics of cancer cells. Besides, we showed that FAM98A and FAM98B are working in the same axis as knockdown of both proteins together does not cause additional reduction in the cellular proliferation and colony formation of colorectal cancer cells.

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More information

Accepted/In Press date: 25 December 2016
e-pub ahead of print date: 28 December 2016
Published date: March 2017

Identifiers

Local EPrints ID: 432625
URI: http://eprints.soton.ac.uk/id/eprint/432625
ISSN: 1099-0461
PURE UUID: c7f296d9-8fe9-4e7e-9d44-5d763ab90a19

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Date deposited: 22 Jul 2019 16:30
Last modified: 22 Jul 2019 16:30

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Contributors

Author: Khondker Ayesha Akter
Author: Toshinori Hyodo
Author: Takeshi Senga

University divisions

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