READ ME File For 'Mechanistic determinants of musculoskeletal health throughout childhood: findings from the Southampton Women’s Survey and the MAVIDOS trial' Dataset DOI: None ReadMe Author: ELIZABETH M CURTIS, University of Southampton ORCID ID https://orcid.org/0000-0002-5147-0550 This dataset supports the thesis entitled "Mechanistic determinants of musculoskeletal health throughout childhood: findings from the Southampton Women’s Survey and the MAVIDOS trial" AWARDED BY: Univeristy of Southampton DATE OF AWARD: [2019] DESCRIPTION OF THE DATA Datasets for the Southampton Women's Survey and MAVIDOS Trial are held by the MRC Lifecourse Epidemiology Unit, University of Southampton. Due to confidentiality requirements the data files cannot be uploaded. They are stored on the P drive at the MRC lifecourse epidemiology unit. Southampton Women's Survey Datasets: The Southampton Women's Survey is a cohort study of mothers and their offspring (n=12,500 prepregnancy) recruited across Southampton. Chapter 4 Methylation at the CDKN2A locus was measured in umbilical cord tissue and was found to be associated with bone outcomes in later childhood. CDKN2A methylation in first 400 individuals: C:\Phil T\Epigen\CDKN2A\CDKN2A & SLC 1st 400 (from lucy final(s)) renamed idsid.dta CDKN2A methylation in second 400 individuals: C:\Phil T\Epigen\CDKN2A\CDKN2A & SLC6A4 2nd 400 cord v2.dta DXA data in the children at age 6 years: P:\0202SWS\Analysis\6yrDXA\6yrdxastat14.dta DXA data in the children at age 4 years: P:\0202SWS\Analysis\4yrDXA\4yrdxastat18 Baby DXA data: P:\0202SWS\Analysis\BabyDXA\babydxastat10 Obstetric Data (maternal): P:\0202SWS\Analysis\Obst\obstat29core.dta Childhood data at age 6 (characteristics): P:\0202SWS\Analysis\6yr\6yrstat12.dta Maternal baseline data: P:\0202SWS\Analysis\Init\initstat28core.dta and P:\0202SWS\Analysis\Init\initstat28.dta Maternal early pregnancy: P:\0202SWS\Analysis\EP\epstat27.dta Maternal late pregnancy: P:\0202SWS\Analysis\LP\lpstat20.dta and P:\0202SWS\Analysis\LP\lpstat20core.dta Maternal late pregnancy bloods: P:\0202SWS\Analysis\LPBloods\lpbloodstat07.dta and P:\0202SWS\Analysis\LPBevitalBloods\lpbevitalbloodsstat04.dta and P:\0202SWS\Analysis\LPVitDBloods\lpvitdbloodstat10.dta Maternal derived variables: P:\0202SWS\Analysis\CombDerivedVars\combderivedvarsstat08.dta MAVIDOS Datasets: MAVIDOS is a randomised controlled trial of cholecalciferol supplementation in pregnancy. Chapter 5: RXRA methylation measurements in umbilical cord at birth: P:\0275mav\Analysis\Cord RXRA\Cord RXRA01.dta Early pregnancy characteristics of mothers: P:\0275mav\Analysis\EP\epstat08.dta Late pregnancy characteristics of mothers: P:\0275mav\Analysis\LP\lpstat08.dta DXA scans of babies at birth: P:\0275mav\Analysis\BabyDXA\babydxastat11.dta Maternal obstetric data: P:\0275mav\Analysis\Obst\obstat06.dta Maternal vitamin D measures: P:\0275mav\Analysis\Vitdcam\Vitdcamstat03.dta Maternal medication compliance data: P:\0275mav\Analysis\Compliance\compliancestat02.dta Chapter 6: Maternal bone turnover markers (CTX) in early pregnancy: P:\0275mav\Analysis\EPctx\epctxstat02.dta Maternal bone turnover markers (CTX) in late pregnancy: P:\0275mav\Analysis\LPctx\lpctxstat02.dta Maternal randomisation group data: P:\0275mav\Analysis\Group\groupstat02.dta Early pregnancy characteristics of mothers: P:\0275mav\Analysis\EP\epstat09.dta Late pregnancy characteristics of mothers: P:\0275mav\Analysis\LP\lpstat08.dta DXA scans of babies at birth: P:\0275mav\Analysis\BabyDXA\babydxastat12.dta Maternal vitamin D measures: P:\0275mav\Analysis\Vitdcam\Vitdcamstat03.dta Maternal obstetric data (season of delivery): P:\0275mav\Analysis\Obst\obstat08.dta Maternal DXA scans: P:\0275mav\Analysis\MaternalDXA\maternalDXAstat01.dta Maternal SNP data: P:\0275mav\Analysis\MaternalSNPs\maternalsnpsstat01.dta Chapter 7: Maternal randomisation group data: P:\0275mav\Analysis\Group\groupstat02.dta Child 4 year DXA data: P:\0275mav\Analysis\4yrDXA\4yrdxasta01.dta Maternal Vitamin D measures: P:\0275mav\Analysis\Vitdcam\Vitdcamstat03.dta Early pregnancy characteristics of mothers: P:\0275mav\Analysis\EP\epstat09.dta Late pregnancy characteristics of mothers: P:\0275mav\Analysis\LP\lpstat08.dta Maternal obstetric data (season of delivery): P:\0275mav\Analysis\Obst\obstat08.dta Maternal medication compliance data: P:\0275mav\Analysis\Compliance\compliancestat02.dta Date of data collection: [JANUARY 2011 to JANUARY 2019]] Information about geographic location of data collection: Three UK hospitals: Southampton, Oxford, Sheffield Related projects/Funders: [This work was supported by grants from Arthritis Research UK, the Medical Research Council (MRC #4050502589), the Bupa Foundation, the National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, the University of Southampton and University Hospital Southampton NHS Foundation Trust, and the NIHR Oxford Biomedical Research Centre, University of Oxford. EC was supported by the Wellcome Trust (#201268/Z/16/Z). The work leading to these results was supported by the European Union's Seventh Framework Programme (#FP7/2007–2013), projects EarlyNutrition and ODIN under grant agreements #289346 and #613977, and by the BBSRC (HDHL-Biomarkers, #BB/P028179/1), as part of the ALPHABET project, supported by an award made through the ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL), Horizon 2020 #696295. We are extremely grateful to Merck GmbH for the kind provision of the Vigantoletten supplement.] Related publications: Elizabeth M Curtis*, Robert Murray*, Philip Titcombe, Rebecca Clarke-Harris, Paula Costello, Emma Garratt, Joanna Holbrook, Sheila Barton, Hazel Inskip, Keith M Godfrey, Christopher Bell, Cyrus Cooper, Karen A Lillycrop, Nicholas C Harvey. Perinatal methylation at CDKN2A locus and offspring bone mass: Findings from the Southampton Women’s Survey. Journal of Bone and Mineral Research. 2017 Oct;32(10):2030-2040 doi: 10.1002/jbmr.3153 Elizabeth M Curtis*, Nevena Krstic*, Eloïse Cook, Stefania D'angelo, Sarah R Crozier, Rebecca J Moon, Robert Murray, Emma Garratt, Paula Costello, Jane Cleal, Brogan Ashley, Nicholas J Bishop, Stephen Kennedy, Aris T Papageorghiou, Inez Schoenmakers, Robert Fraser, Saurabh V Gandhi, Ann Prentice, M Kassim Javaid, Hazel M Inskip, Keith M Godfrey, Christopher G Bell, Karen A Lillycrop, Cyrus Cooper, Nicholas C Harvey, MAVIDOS Trial Group. Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: Results from the MAVIDOS trial. Journal of Bone and Mineral Research. 2019 Feb; 34(2):231-240 doi: 10.1002/jbmr.3603 Date that the file was created: July, 2019 --------------