Continuous flow production of size-controllable niosomes using a thermostatic microreactor
Continuous flow production of size-controllable niosomes using a thermostatic microreactor
The new roles of vesicular systems in advanced biomedical, analytical and food science applications demand novel preparation processes designed to reach the new standards. Particle size and monodispersity have become essential properties to control. In this work, key parameters, involved in a microfluidic reactor with hydrodynamic flow focusing, were investigated in order to quantify their effects on niosomes morphology. Particular attention was given to temperature, which is both a requirement to handle non-ionic surfactants with phase transition temperature above RT, and a tailoring variable for size and monodispersity control. With this aim, niosomes with two different sorbitan esters and cholesterol as stabilizer were formulated. High resolution and conventional 3D-printing technologies were employed for the fabrication of microfluidic reactor and thermostatic systems, since this additive technology has been essential for microfluidics development in terms of cost-effective and rapid prototyping. A customised device to control temperature and facilitate visualization of the process was developed, which can be easily coupled with commercial inverted microscopes. The results demonstrated the capability of microfluidic production of niosomes within the full range of non-ionic surfactants and membrane stabilizers.
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Garcia Manrique, Pablo
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Gutiérrez, Gemma
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Matos, María
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Cristaldi, Domenico, Andrea
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Mosayyebi, Ali
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Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Zhang, Xunli
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Blanco-López, María Carmen
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1 October 2019
Garcia Manrique, Pablo
f42704b0-9c39-4b1b-b31b-eef7a22221b0
Gutiérrez, Gemma
1aec0e43-7f50-4d3b-9429-3672507c1b0b
Matos, María
b568aa21-f527-42d1-83f1-e307bd889634
Cristaldi, Domenico, Andrea
6da2333e-3305-4a8b-996f-e5a844c69cdc
Mosayyebi, Ali
ab9cf6da-58c4-4441-993b-7d03d5d3549a
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Blanco-López, María Carmen
18a1fc9f-f73c-4691-b284-becc5901e8f4
Garcia Manrique, Pablo, Gutiérrez, Gemma, Matos, María, Cristaldi, Domenico, Andrea, Mosayyebi, Ali, Carugo, Dario, Zhang, Xunli and Blanco-López, María Carmen
(2019)
Continuous flow production of size-controllable niosomes using a thermostatic microreactor.
Colloids and Surfaces B: Biointerfaces, 182, , [110378].
(doi:10.1016/j.colsurfb.2019.110378).
Abstract
The new roles of vesicular systems in advanced biomedical, analytical and food science applications demand novel preparation processes designed to reach the new standards. Particle size and monodispersity have become essential properties to control. In this work, key parameters, involved in a microfluidic reactor with hydrodynamic flow focusing, were investigated in order to quantify their effects on niosomes morphology. Particular attention was given to temperature, which is both a requirement to handle non-ionic surfactants with phase transition temperature above RT, and a tailoring variable for size and monodispersity control. With this aim, niosomes with two different sorbitan esters and cholesterol as stabilizer were formulated. High resolution and conventional 3D-printing technologies were employed for the fabrication of microfluidic reactor and thermostatic systems, since this additive technology has been essential for microfluidics development in terms of cost-effective and rapid prototyping. A customised device to control temperature and facilitate visualization of the process was developed, which can be easily coupled with commercial inverted microscopes. The results demonstrated the capability of microfluidic production of niosomes within the full range of non-ionic surfactants and membrane stabilizers.
Text
Accepted COLSUB-D-19-00534R1
- Accepted Manuscript
More information
Accepted/In Press date: 17 July 2019
e-pub ahead of print date: 18 July 2019
Published date: 1 October 2019
Identifiers
Local EPrints ID: 432732
URI: http://eprints.soton.ac.uk/id/eprint/432732
PURE UUID: 1627480b-a076-451a-8d41-2e62c9eba09a
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Date deposited: 25 Jul 2019 16:30
Last modified: 21 Nov 2024 05:02
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Contributors
Author:
Pablo Garcia Manrique
Author:
Gemma Gutiérrez
Author:
María Matos
Author:
Ali Mosayyebi
Author:
María Carmen Blanco-López
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