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Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning

Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning
Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning

OBJECTIVE: To determine the effect of remote ischemic preconditioning (RIPC) on dynamic cerebral autoregulation (dCA) and various blood biomarkers in healthy adults. METHODS: A self-controlled interventional study was conducted. Serial measurements of dCA were performed at 7 time points (7, 9, and 11 am; 2, 5, and 8 pm, and 8 am on the next day) without or with RIPC, carried out at 7:20 to 8 am. Venous blood samples were collected at baseline (7 am) and 1 hour after RIPC, and blood biomarkers, including 5 neuroprotective factors and 25 inflammation-related biomarkers, were measured with a quantitative protein chip. RESULTS: Fifty participants were enrolled (age 34.54 ± 12.01 years, 22 men). Compared with the results on the day without RIPC, dCA was significantly increased at 6 hours after RIPC, and the increase was sustained for at least 24 hours. After RIPC, 2 neuroprotective factors (glial cell-derived neurotrophic factor and vascular endothelial growth factor-A) and 4 inflammation-related biomarkers (transforming growth factor-β1, leukemia inhibitory factor, matrix metallopeptidase-9, and tissue inhibitor of metalloproteinase-1) were significantly elevated compared with their baseline levels. Conversely, monocyte chemoattractant protein-1 was significantly lower compared with its baseline level. CONCLUSIONS: RIPC induces a sustained increase of dCA from 6 to at least 24 hours after treatment in healthy adults. In addition, several neuroprotective and inflammation-related blood biomarkers were differentially regulated shortly after RIPC. The increased dCA and altered blood biomarkers may collectively contribute to the beneficial effects of RIPC on cerebrovascular function. CLINICALTRIALSGOV IDENTIFIER: NCT02965547.

0028-3878
e8-e19
Guo, Zhen Ni
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Guo, Wei Tong
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Liu, Jia
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Chang, Junlei
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Ma, Hongyin
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Zhang, Peng
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Zhang, Fu Liang
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Han, Ke
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Hu, Han Hwa
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Jin, Hang
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Sun, Xin
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Simpson, David Martin
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Yang, Yi
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Guo, Zhen Ni
4327fb17-b308-4ae4-b33d-ee32b580ddca
Guo, Wei Tong
d93bf0ae-a28b-434a-b0e0-4c99003cc42b
Liu, Jia
0b8a8611-d480-4611-9c81-e5a9e5eea30e
Chang, Junlei
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Ma, Hongyin
7da25677-1629-4d0c-af35-c8b0664bae69
Zhang, Peng
3b7dc273-0330-4b17-91a5-0075836e098d
Zhang, Fu Liang
bd0e722d-2950-49d1-9654-4ae4ad40b54d
Han, Ke
a4455724-45f5-448a-b4a7-51f339321612
Hu, Han Hwa
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Jin, Hang
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Sun, Xin
286c317b-c8c0-47f5-bc9c-bfe8f9edd36b
Simpson, David Martin
53674880-f381-4cc9-8505-6a97eeac3c2a
Yang, Yi
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Guo, Zhen Ni, Guo, Wei Tong, Liu, Jia, Chang, Junlei, Ma, Hongyin, Zhang, Peng, Zhang, Fu Liang, Han, Ke, Hu, Han Hwa, Jin, Hang, Sun, Xin, Simpson, David Martin and Yang, Yi (2019) Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning. Neurology, 93 (1), e8-e19. (doi:10.1212/WNL.0000000000007732).

Record type: Article

Abstract

OBJECTIVE: To determine the effect of remote ischemic preconditioning (RIPC) on dynamic cerebral autoregulation (dCA) and various blood biomarkers in healthy adults. METHODS: A self-controlled interventional study was conducted. Serial measurements of dCA were performed at 7 time points (7, 9, and 11 am; 2, 5, and 8 pm, and 8 am on the next day) without or with RIPC, carried out at 7:20 to 8 am. Venous blood samples were collected at baseline (7 am) and 1 hour after RIPC, and blood biomarkers, including 5 neuroprotective factors and 25 inflammation-related biomarkers, were measured with a quantitative protein chip. RESULTS: Fifty participants were enrolled (age 34.54 ± 12.01 years, 22 men). Compared with the results on the day without RIPC, dCA was significantly increased at 6 hours after RIPC, and the increase was sustained for at least 24 hours. After RIPC, 2 neuroprotective factors (glial cell-derived neurotrophic factor and vascular endothelial growth factor-A) and 4 inflammation-related biomarkers (transforming growth factor-β1, leukemia inhibitory factor, matrix metallopeptidase-9, and tissue inhibitor of metalloproteinase-1) were significantly elevated compared with their baseline levels. Conversely, monocyte chemoattractant protein-1 was significantly lower compared with its baseline level. CONCLUSIONS: RIPC induces a sustained increase of dCA from 6 to at least 24 hours after treatment in healthy adults. In addition, several neuroprotective and inflammation-related blood biomarkers were differentially regulated shortly after RIPC. The increased dCA and altered blood biomarkers may collectively contribute to the beneficial effects of RIPC on cerebrovascular function. CLINICALTRIALSGOV IDENTIFIER: NCT02965547.

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Accepted/In Press date: 14 February 2019
e-pub ahead of print date: 29 May 2019
Published date: 2 July 2019

Identifiers

Local EPrints ID: 432754
URI: https://eprints.soton.ac.uk/id/eprint/432754
ISSN: 0028-3878
PURE UUID: d79ad2ba-54b8-4b4f-ad0d-de4804feb3fd

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Date deposited: 26 Jul 2019 16:30
Last modified: 28 Aug 2019 16:31

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Contributors

Author: Zhen Ni Guo
Author: Wei Tong Guo
Author: Jia Liu
Author: Junlei Chang
Author: Hongyin Ma
Author: Peng Zhang
Author: Fu Liang Zhang
Author: Ke Han
Author: Han Hwa Hu
Author: Hang Jin
Author: Xin Sun
Author: Yi Yang

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