Multiplexed detection of CRP-SAA1 using laser direct-write-fabricated multiple flow-path lateral flow devices
Multiplexed detection of CRP-SAA1 using laser direct-write-fabricated multiple flow-path lateral flow devices
We report a novel solution to allow multiplexed detection using a multi-path LFD that is fabricated via the precise partition of the flow-path of a single LFD using a laser direct-write technique. The multiple flow-paths allow individual detection of different analytes in each of the separated channels. We have successfully demonstrated the use of these multi-path LFDs for simultaneous detection of a biomarker panel comprising CRP and SAA-1, commonly used for the diagnosis of bacterial infections. In addition, clinical samples have also been tested and the results show a high consistency with those acquired using the gold-standard ELISA test.
He, Peijun
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Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
Galanis, Panagiotis
4457b788-deef-4293-ab39-76f501b9529d
Teeling, Jessica
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Eason, Robert
e38684c3-d18c-41b9-a4aa-def67283b020
Sones, Collin
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
February 2019
He, Peijun
2e303166-6aa5-4a09-b22e-440d96a54a9f
Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
Galanis, Panagiotis
4457b788-deef-4293-ab39-76f501b9529d
Teeling, Jessica
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Eason, Robert
e38684c3-d18c-41b9-a4aa-def67283b020
Sones, Collin
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
He, Peijun, Katis, Ioannis, Galanis, Panagiotis, Teeling, Jessica, Holmes, Clive, Eason, Robert and Sones, Collin
(2019)
Multiplexed detection of CRP-SAA1 using laser direct-write-fabricated multiple flow-path lateral flow devices.
Gray, Bonnie L. and Becker, Holger
(eds.)
In Microfluidics, BioMEMS, and Medical Microsystems XVII.
vol. 10875,
SPIE..
(doi:10.1117/12.2532080).
Record type:
Conference or Workshop Item
(Paper)
Abstract
We report a novel solution to allow multiplexed detection using a multi-path LFD that is fabricated via the precise partition of the flow-path of a single LFD using a laser direct-write technique. The multiple flow-paths allow individual detection of different analytes in each of the separated channels. We have successfully demonstrated the use of these multi-path LFDs for simultaneous detection of a biomarker panel comprising CRP and SAA-1, commonly used for the diagnosis of bacterial infections. In addition, clinical samples have also been tested and the results show a high consistency with those acquired using the gold-standard ELISA test.
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Published date: February 2019
Venue - Dates:
Photonics West, The Moscone Center, San Francisco, United States, 2019-02-01 - 2019-02-06
Identifiers
Local EPrints ID: 432779
URI: http://eprints.soton.ac.uk/id/eprint/432779
PURE UUID: 13a092ec-92d6-4542-b764-48821dc6b76c
Catalogue record
Date deposited: 26 Jul 2019 16:30
Last modified: 17 Mar 2024 02:35
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Contributors
Author:
Panagiotis Galanis
Editor:
Bonnie L. Gray
Editor:
Holger Becker
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