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Systematic review: long-term cognitive and behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy in children without cerebral palsy

Systematic review: long-term cognitive and behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy in children without cerebral palsy
Systematic review: long-term cognitive and behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy in children without cerebral palsy
AIM:

To evaluate long-term cognitive and behavioural outcomes of children with neonatal hypoxic-ischaemic encephalopathy (HIE) in the absence of cerebral palsy (CP).

METHODS:

A systematic search was performed on five databases (EMBASE, Medline, PubMed, Web of Science, PsycInfo). Randomised controlled trials, non-randomised controlled trials, or observational studies, published between 1990 and 2017, that reported long-term (age greater than or equal to four years) cognitive and/or behavioural outcomes of neonatal HIE without CP were included.

RESULTS:

Seven articles met the inclusion criteria (n = 352 total participants, n = 53 treated with therapeutic hypothermia). Studies reporting cognitive outcome demonstrate impairment of general cognitive abilities in 25-63% of participants with HIE without CP. Specific cognitive difficulties were reported in two studies for attention, executive functioning, memory function and language. Results regarding behavioural outcome possibly indicate a higher risk of difficulties.

CONCLUSION:

A substantial proportion of children with neonatal HIE who survive without CP are at increased risk of general and/or specific cognitive impairments. Behavioural problems may be more common, but evidence is limited. Results highlight the importance of comprehensive long-term follow-up to identity difficulties and enable intervention to optimise educational achievement and behavioural adjustment.
0803-5253
Schreglmann, Magdalena
cc822ee0-198d-41f2-bf21-db5a7b6866fe
Ground, Amy
c51ce079-ade8-4205-a555-750e784f87db
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Johnson, Mark J.
ce07b5dd-b12b-47df-a5df-cd3b9447c9ed
Schreglmann, Magdalena
cc822ee0-198d-41f2-bf21-db5a7b6866fe
Ground, Amy
c51ce079-ade8-4205-a555-750e784f87db
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Johnson, Mark J.
ce07b5dd-b12b-47df-a5df-cd3b9447c9ed

Schreglmann, Magdalena, Ground, Amy, Vollmer, Brigitte and Johnson, Mark J. (2019) Systematic review: long-term cognitive and behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy in children without cerebral palsy. Acta Paediatrica. (doi:10.1111/apa.14821).

Record type: Review

Abstract

AIM:

To evaluate long-term cognitive and behavioural outcomes of children with neonatal hypoxic-ischaemic encephalopathy (HIE) in the absence of cerebral palsy (CP).

METHODS:

A systematic search was performed on five databases (EMBASE, Medline, PubMed, Web of Science, PsycInfo). Randomised controlled trials, non-randomised controlled trials, or observational studies, published between 1990 and 2017, that reported long-term (age greater than or equal to four years) cognitive and/or behavioural outcomes of neonatal HIE without CP were included.

RESULTS:

Seven articles met the inclusion criteria (n = 352 total participants, n = 53 treated with therapeutic hypothermia). Studies reporting cognitive outcome demonstrate impairment of general cognitive abilities in 25-63% of participants with HIE without CP. Specific cognitive difficulties were reported in two studies for attention, executive functioning, memory function and language. Results regarding behavioural outcome possibly indicate a higher risk of difficulties.

CONCLUSION:

A substantial proportion of children with neonatal HIE who survive without CP are at increased risk of general and/or specific cognitive impairments. Behavioural problems may be more common, but evidence is limited. Results highlight the importance of comprehensive long-term follow-up to identity difficulties and enable intervention to optimise educational achievement and behavioural adjustment.

Full text not available from this repository.

More information

Accepted/In Press date: 15 April 2019
e-pub ahead of print date: 19 April 2019

Identifiers

Local EPrints ID: 432792
URI: https://eprints.soton.ac.uk/id/eprint/432792
ISSN: 0803-5253
PURE UUID: c7d8b457-1efa-4355-a1f9-b7a59f19ccde
ORCID for Brigitte Vollmer: ORCID iD orcid.org/0000-0003-4088-5336
ORCID for Mark J. Johnson: ORCID iD orcid.org/0000-0003-1829-9912

Catalogue record

Date deposited: 26 Jul 2019 16:30
Last modified: 27 Jul 2019 00:32

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