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Nuclear phosphoinositides: their regulation and roles in nuclear functions

Nuclear phosphoinositides: their regulation and roles in nuclear functions
Nuclear phosphoinositides: their regulation and roles in nuclear functions

Polyphosphoinositides (PPIns) are a family of seven lipid messengers that regulate a vast array of signalling pathways to control cell proliferation, migration, survival and differentiation. PPIns are differentially present in various sub-cellular compartments and, through the recruitment and regulation of specific proteins, are key regulators of compartment identity and function. Phosphoinositides and the enzymes that synthesise and degrade them are also present in the nuclear membrane and in nuclear membraneless compartments such as nuclear speckles. Here we discuss how PPIns in the nucleus are modulated in response to external cues and how they function to control downstream signalling. Finally we suggest a role for nuclear PPIns in liquid phase separations that are involved in the formation of membraneless compartments within the nucleus.

demixing, epigenetic signalling, lipid kinase, liquid-liquid phase separation, nucleus, phosphoinositides, phospholipase C, PtdIns(4,5)P2, PtdIns5P
1422-0067
Fiume, R.
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Faenza, I.
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Sheth, B.
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Poli, A.
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Vidalle, M. C.
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Mazzetti, C.
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Abdul, S. H.
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Campagnoli, F.
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Fabbrini, M.
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Kimber, S. T.
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Mariani, G. A.
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Xian, J.
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Marvi, M. V.
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Mongiorgi, S.
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Shah, Z.
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Divecha, N.
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Fiume, R.
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Faenza, I.
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Sheth, B.
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Poli, A.
b34b928d-f5c2-4544-b969-201cb5bbedfc
Vidalle, M. C.
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Mazzetti, C.
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Abdul, S. H.
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Campagnoli, F.
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Fabbrini, M.
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Kimber, S. T.
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Mariani, G. A.
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Xian, J.
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Marvi, M. V.
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Mongiorgi, S.
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Shah, Z.
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Divecha, N.
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Fiume, R., Faenza, I., Sheth, B., Poli, A., Vidalle, M. C., Mazzetti, C., Abdul, S. H., Campagnoli, F., Fabbrini, M., Kimber, S. T., Mariani, G. A., Xian, J., Marvi, M. V., Mongiorgi, S., Shah, Z. and Divecha, N. (2019) Nuclear phosphoinositides: their regulation and roles in nuclear functions. International Journal of Molecular Sciences, 20 (12). (doi:10.3390/ijms20122991).

Record type: Review

Abstract

Polyphosphoinositides (PPIns) are a family of seven lipid messengers that regulate a vast array of signalling pathways to control cell proliferation, migration, survival and differentiation. PPIns are differentially present in various sub-cellular compartments and, through the recruitment and regulation of specific proteins, are key regulators of compartment identity and function. Phosphoinositides and the enzymes that synthesise and degrade them are also present in the nuclear membrane and in nuclear membraneless compartments such as nuclear speckles. Here we discuss how PPIns in the nucleus are modulated in response to external cues and how they function to control downstream signalling. Finally we suggest a role for nuclear PPIns in liquid phase separations that are involved in the formation of membraneless compartments within the nucleus.

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Accepted/In Press date: 17 June 2019
Published date: 19 June 2019
Keywords: demixing, epigenetic signalling, lipid kinase, liquid-liquid phase separation, nucleus, phosphoinositides, phospholipase C, PtdIns(4,5)P2, PtdIns5P

Identifiers

Local EPrints ID: 432836
URI: http://eprints.soton.ac.uk/id/eprint/432836
ISSN: 1422-0067
PURE UUID: 01b560bb-8798-4613-9846-a1326ceba939

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Date deposited: 29 Jul 2019 16:30
Last modified: 16 Mar 2024 03:08

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Contributors

Author: R. Fiume
Author: I. Faenza
Author: B. Sheth
Author: A. Poli
Author: M. C. Vidalle
Author: C. Mazzetti
Author: S. H. Abdul
Author: F. Campagnoli
Author: M. Fabbrini
Author: S. T. Kimber
Author: G. A. Mariani
Author: J. Xian
Author: M. V. Marvi
Author: S. Mongiorgi
Author: Z. Shah
Author: N. Divecha

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