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Ultrasound mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge

Ultrasound mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge
Ultrasound mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge
Bacterial biofilms are an ever-growing concern for public health; featuring both inherited genetic resistance and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a growing interest in novel methods of drug delivery, in order to increase the efficacy of antimicrobial agents. One such method is the use of acoustically activated microbubbles, which undergo volumetric oscillations and collapse upon exposure to an ultrasound field. This facilitates physical perturbation of the biofilm, and provides the means to control drug delivery both temporally and spatially. In line with current literature in this area, this review offers a rounded argument for why ultrasound-responsive agents could be an integral part of advancing wound care. To achieve this, we will outline the development and clinical significance of biofilms in the context of chronic infections. We will then discuss current practices used in combating biofilms in chronic wounds, and then critically evaluate the use of acoustically activated gas microbubbles as an emerging treatment modality. Moreover, we will introduce the novel concept of microbubbles carrying biologically active gases that may facilitate biofilm dispersal.
1751-7907
Lutheryn, Gareth, William Edward
90e2ecc4-745e-4fe1-b109-77cfed5317bf
Glynne-Jones, Peter
6ca3fcbc-14db-4af9-83e2-cf7c8b91ef0d
Webb, Jeremy
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Lutheryn, Gareth, William Edward
90e2ecc4-745e-4fe1-b109-77cfed5317bf
Glynne-Jones, Peter
6ca3fcbc-14db-4af9-83e2-cf7c8b91ef0d
Webb, Jeremy
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179

Lutheryn, Gareth, William Edward, Glynne-Jones, Peter, Webb, Jeremy and Carugo, Dario (2019) Ultrasound mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge. Microbial Biotechnology. (doi:10.1111/1751-7915.13471).

Record type: Article

Abstract

Bacterial biofilms are an ever-growing concern for public health; featuring both inherited genetic resistance and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a growing interest in novel methods of drug delivery, in order to increase the efficacy of antimicrobial agents. One such method is the use of acoustically activated microbubbles, which undergo volumetric oscillations and collapse upon exposure to an ultrasound field. This facilitates physical perturbation of the biofilm, and provides the means to control drug delivery both temporally and spatially. In line with current literature in this area, this review offers a rounded argument for why ultrasound-responsive agents could be an integral part of advancing wound care. To achieve this, we will outline the development and clinical significance of biofilms in the context of chronic infections. We will then discuss current practices used in combating biofilms in chronic wounds, and then critically evaluate the use of acoustically activated gas microbubbles as an emerging treatment modality. Moreover, we will introduce the novel concept of microbubbles carrying biologically active gases that may facilitate biofilm dispersal.

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More information

Accepted/In Press date: 22 July 2019
e-pub ahead of print date: 7 August 2019

Identifiers

Local EPrints ID: 432897
URI: http://eprints.soton.ac.uk/id/eprint/432897
ISSN: 1751-7907
PURE UUID: 348c3e62-8e50-4b40-a6d9-57b517cddbb3
ORCID for Peter Glynne-Jones: ORCID iD orcid.org/0000-0001-5684-3953
ORCID for Jeremy Webb: ORCID iD orcid.org/0000-0003-2068-8589

Catalogue record

Date deposited: 31 Jul 2019 16:30
Last modified: 18 Feb 2021 17:08

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