Associations between specific plasma ceramides and severity of coronary-artery stenosis assessed by coronary angiography
Associations between specific plasma ceramides and severity of coronary-artery stenosis assessed by coronary angiography
Aim: Recent prospective studies have identified distinct plasma ceramides as strong predictors of major adverse cardiovascular events in patients with established or suspected coronary artery disease (CAD). Currently, it is uncertain whether higher levels of distinct plasma ceramides are also associated with greater angiographic severity of coronary-artery stenoses in this patient population.
Methods: We measured six previously identified high-risk plasma ceramide species [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0) and Cer(d18:1/24:1)] in 167 consecutive patients with established or suspected CAD, who underwent urgent or elective coronary angiography.
Results: Approximately 77% of patients had a significant stenosis (≥50%) in one or more of the main coronary arteries, the majority of whom (~60%) had a significant stenosis in the left anterior descending (LAD) artery. Of the six measured plasma ceramides, higher levels of plasma Cer(d18:1/20:0) (adjusted-odds ratio 1.39, 95%CI 1.0-1.99), Cer(d18:1/22:0) (adjusted-odds ratio 1.57, 95%CI 1.08-2.29) and Cer(d18:1/24:0) (adjusted-odds ratio 1.59, 95%CI 1.08-2.32) were significantly associated with the presence of LAD stenosis ≥ 50%, after adjustment for age, sex, smoking, pre-existing CAD, hypertension, diabetes, dyslipidaemia, lipid-lowering therapy, estimated glomerular filtration rate and plasma C-reactive protein levels. Almost identical results were found even after excluding patients (n=15) with acute ST-elevation myocardial infarction. Similar results were also found when patients were categorized according to Gensini severity score.
Conclusion: Our cross-sectional study shows for the first time that higher levels of specific plasma ceramides are independently associated with a greater severity of coronary-artery stenoses in the LAD artery in patients who had suspected or established CAD.
Ceramides, Coronary angiography, Coronary artery disease, Risk factors
150-157
Mantovani, Alessandro
19fc8a1f-60fe-403a-b70e-6b6884929e03
Bonapace, Stefano
105831ba-c8a5-43f4-9cc6-f38cbff04934
Lunardi, Gianluigi
6ebb046e-ec04-41e3-9e67-d43a511673b4
Canali, Guido
8aaf417c-8ced-4913-a32d-54b81b2419da
Dugo, Clementina
809dd599-bd0e-41f4-9a01-06159814d138
Vinco, Giulia
401a47e8-6b49-4356-89c3-47c3921b2b7b
Calabria, Stefano
8b625687-c7cb-46c2-90a4-3ab8b55f7901
Barbieri, Enrico
775497bf-5210-49ff-b736-ce67817caf8e
Laaksonen, Reijo
181f4c15-171a-4611-a51b-9a72283b443e
Bonnet, Fabrice
83f8ab80-5098-4790-b8cb-a76f8508a77c
Byrne, Chris
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
April 2020
Mantovani, Alessandro
19fc8a1f-60fe-403a-b70e-6b6884929e03
Bonapace, Stefano
105831ba-c8a5-43f4-9cc6-f38cbff04934
Lunardi, Gianluigi
6ebb046e-ec04-41e3-9e67-d43a511673b4
Canali, Guido
8aaf417c-8ced-4913-a32d-54b81b2419da
Dugo, Clementina
809dd599-bd0e-41f4-9a01-06159814d138
Vinco, Giulia
401a47e8-6b49-4356-89c3-47c3921b2b7b
Calabria, Stefano
8b625687-c7cb-46c2-90a4-3ab8b55f7901
Barbieri, Enrico
775497bf-5210-49ff-b736-ce67817caf8e
Laaksonen, Reijo
181f4c15-171a-4611-a51b-9a72283b443e
Bonnet, Fabrice
83f8ab80-5098-4790-b8cb-a76f8508a77c
Byrne, Chris
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Mantovani, Alessandro, Bonapace, Stefano, Lunardi, Gianluigi, Canali, Guido, Dugo, Clementina, Vinco, Giulia, Calabria, Stefano, Barbieri, Enrico, Laaksonen, Reijo, Bonnet, Fabrice, Byrne, Chris and Targher, Giovanni
(2020)
Associations between specific plasma ceramides and severity of coronary-artery stenosis assessed by coronary angiography.
Diabetes & Metabolism, 46 (2), .
(doi:10.1016/j.diabet.2019.07.006).
Abstract
Aim: Recent prospective studies have identified distinct plasma ceramides as strong predictors of major adverse cardiovascular events in patients with established or suspected coronary artery disease (CAD). Currently, it is uncertain whether higher levels of distinct plasma ceramides are also associated with greater angiographic severity of coronary-artery stenoses in this patient population.
Methods: We measured six previously identified high-risk plasma ceramide species [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0) and Cer(d18:1/24:1)] in 167 consecutive patients with established or suspected CAD, who underwent urgent or elective coronary angiography.
Results: Approximately 77% of patients had a significant stenosis (≥50%) in one or more of the main coronary arteries, the majority of whom (~60%) had a significant stenosis in the left anterior descending (LAD) artery. Of the six measured plasma ceramides, higher levels of plasma Cer(d18:1/20:0) (adjusted-odds ratio 1.39, 95%CI 1.0-1.99), Cer(d18:1/22:0) (adjusted-odds ratio 1.57, 95%CI 1.08-2.29) and Cer(d18:1/24:0) (adjusted-odds ratio 1.59, 95%CI 1.08-2.32) were significantly associated with the presence of LAD stenosis ≥ 50%, after adjustment for age, sex, smoking, pre-existing CAD, hypertension, diabetes, dyslipidaemia, lipid-lowering therapy, estimated glomerular filtration rate and plasma C-reactive protein levels. Almost identical results were found even after excluding patients (n=15) with acute ST-elevation myocardial infarction. Similar results were also found when patients were categorized according to Gensini severity score.
Conclusion: Our cross-sectional study shows for the first time that higher levels of specific plasma ceramides are independently associated with a greater severity of coronary-artery stenoses in the LAD artery in patients who had suspected or established CAD.
Text
Ceramides and CGF_Diabetes Metabolism_accepted
- Accepted Manuscript
Text
Supplementary Tables_accepted
- Accepted Manuscript
More information
Accepted/In Press date: 26 July 2019
e-pub ahead of print date: 3 August 2019
Published date: April 2020
Additional Information:
Funding Information:
GT is supported in part by grants from the University School of Medicine of Verona , Verona, Italy; CDB is supported in part by grants from the Southampton National Institute for Health Research Biomedical Research Centre .
Publisher Copyright:
© 2019 Elsevier Masson SAS
Keywords:
Ceramides, Coronary angiography, Coronary artery disease, Risk factors
Identifiers
Local EPrints ID: 433009
URI: http://eprints.soton.ac.uk/id/eprint/433009
ISSN: 1262-3636
PURE UUID: fe75a646-4820-4a93-959e-378b12d24864
Catalogue record
Date deposited: 06 Aug 2019 16:30
Last modified: 17 Mar 2024 02:49
Export record
Altmetrics
Contributors
Author:
Alessandro Mantovani
Author:
Stefano Bonapace
Author:
Gianluigi Lunardi
Author:
Guido Canali
Author:
Clementina Dugo
Author:
Giulia Vinco
Author:
Stefano Calabria
Author:
Enrico Barbieri
Author:
Reijo Laaksonen
Author:
Fabrice Bonnet
Author:
Giovanni Targher
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
