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Proteomic approaches to dissect neuronal signalling pathways

Proteomic approaches to dissect neuronal signalling pathways
Proteomic approaches to dissect neuronal signalling pathways
With an increasing awareness of mental health issues and neurological disorders, “understanding the brain” is one of the biggest current challenges in biological research. This has been recognised by both governments and funding agencies, and it includes the need to understand connectivity of brain regions and coordinated network activity, as well as cellular and molecular mechanisms at play. In this chapter, we will describe how we have taken advantage of different proteomic techniques to unravel molecular mechanisms underlying two modulators of neuronal function: Neurotrophins and antipsychotics.
469-475
Springer, Cham
Bowling, Heather
a46a33bf-490b-4daf-901e-bc51c226a700
Nayak, Shruti
2dc7daa0-dc9e-416c-af3e-9ce09303ec79
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1
Woods, A.
Darie, C.
Bowling, Heather
a46a33bf-490b-4daf-901e-bc51c226a700
Nayak, Shruti
2dc7daa0-dc9e-416c-af3e-9ce09303ec79
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1
Woods, A.
Darie, C.

Bowling, Heather, Nayak, Shruti and Deinhardt, Katrin (2019) Proteomic approaches to dissect neuronal signalling pathways. In, Woods, A. and Darie, C. (eds.) Advancements of Mass Spectrometry in Biomedical Research. Cham. Springer, Cham, pp. 469-475. (doi:10.1007/978-3-030-15950-4_27).

Record type: Book Section

Abstract

With an increasing awareness of mental health issues and neurological disorders, “understanding the brain” is one of the biggest current challenges in biological research. This has been recognised by both governments and funding agencies, and it includes the need to understand connectivity of brain regions and coordinated network activity, as well as cellular and molecular mechanisms at play. In this chapter, we will describe how we have taken advantage of different proteomic techniques to unravel molecular mechanisms underlying two modulators of neuronal function: Neurotrophins and antipsychotics.

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More information

e-pub ahead of print date: 26 July 2019

Identifiers

Local EPrints ID: 433066
URI: http://eprints.soton.ac.uk/id/eprint/433066
PURE UUID: 44ff8109-e26b-4857-b05e-4880f33f7c60
ORCID for Katrin Deinhardt: ORCID iD orcid.org/0000-0002-6473-5298

Catalogue record

Date deposited: 07 Aug 2019 16:30
Last modified: 10 Nov 2021 03:32

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Contributors

Author: Heather Bowling
Author: Shruti Nayak
Editor: A. Woods
Editor: C. Darie

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