The University of Southampton
University of Southampton Institutional Repository

Advances in parahydrogen-enhanced nuclear magnetic resonance

Advances in parahydrogen-enhanced nuclear magnetic resonance
Advances in parahydrogen-enhanced nuclear magnetic resonance
Nuclear magnetic resonance is a powerful spectroscopic tool, which has found applications in fields such as chemistry, the life sciences, medical imaging, and even fundamental physics, but is often limited by the low polarization of nuclear spins in ambient conditions. Hyperpolarization techniques are used to increase the spin polarization, which can lead to large signal enhancements. In the context of magnetic resonance imaging, this can allow for in vivo observation of metabolites at physiological concentrations, which would otherwise not be possible given current sensitivity limits.

This thesis describes a number of hyperpolarization methods and their applications to in vivo imaging, with particular emphasis on parahydrogen-induced hyperpolarization. This technique allows for the production hyperpolarized samples via chemical reaction with a specific spin-isomer of hydrogen gas. Theory and experiments for producing hyperpolarized samples are described that advance this methodology towards eventual clinical application
University of Southampton
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Levitt, Malcolm
bcc5a80a-e5c5-4e0e-9a9a-249d036747c3

Eills, James (2019) Advances in parahydrogen-enhanced nuclear magnetic resonance. University of Southampton, Doctoral Thesis, 181pp.

Record type: Thesis (Doctoral)

Abstract

Nuclear magnetic resonance is a powerful spectroscopic tool, which has found applications in fields such as chemistry, the life sciences, medical imaging, and even fundamental physics, but is often limited by the low polarization of nuclear spins in ambient conditions. Hyperpolarization techniques are used to increase the spin polarization, which can lead to large signal enhancements. In the context of magnetic resonance imaging, this can allow for in vivo observation of metabolites at physiological concentrations, which would otherwise not be possible given current sensitivity limits.

This thesis describes a number of hyperpolarization methods and their applications to in vivo imaging, with particular emphasis on parahydrogen-induced hyperpolarization. This technique allows for the production hyperpolarized samples via chemical reaction with a specific spin-isomer of hydrogen gas. Theory and experiments for producing hyperpolarized samples are described that advance this methodology towards eventual clinical application

Text
Thesis Eills - corrected unsigned - Version of Record
Available under License University of Southampton Thesis Licence.
Download (53MB)

More information

Published date: 28 April 2019

Identifiers

Local EPrints ID: 433123
URI: http://eprints.soton.ac.uk/id/eprint/433123
PURE UUID: cf640e2a-516b-420d-a250-6a2e2fa8588e
ORCID for Malcolm Levitt: ORCID iD orcid.org/0000-0001-9878-1180

Catalogue record

Date deposited: 08 Aug 2019 16:30
Last modified: 09 Aug 2019 00:37

Export record

Contributors

Author: James Eills
Thesis advisor: Malcolm Levitt ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×