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Albuminuria and sodiuria in IUGR children

Albuminuria and sodiuria in IUGR children
Albuminuria and sodiuria in IUGR children
Objective: Intrauterine growth restriction (IUGR) is associated with hyperfiltration, glomerulosclerosis and albuminuria. Albuminuria may further lead to tubulointerstitial inflammation, fibrosis and tubular atrophy. The time at which this may occur is unknown. This study was designed to assess the relationship between glomerular and tubular damage in IUGR children. Methods: We enrolled 50 children, 25 IUGR, categorized by estimated fetal weight <10th percentile and umbilical artery pulsatility index >2 SD, and 25 appropriate for gestational age (AGA) controls at 18 months of age. We compared albuminuria among IUGR and AGA children, to assess the relationship between albuminuria and contemporary sodium and lysozyme excretion, as a measure of tubular damage. Results: The albumin-creatinine (mg/g) and sodium-creatinine (μM/L) ratios (3.12 and 441.3, versus 1.39 and 226.1 in AGA; p = 0.002 and p = 0.012, respectively) were significantly higher in the IUGR subjects compared with AGA children, and significantly correlated (rho = 0.593, p = 0.002). Conversely, urinary lysozyme was undetectable or in normal excretion range. Conclusions: Our results show glomerulosclerosis and albuminuria in IUGR children aged 18 months. Elevated sodium excretion in the absence of abnormal lysozymuria may represent a epiphenomenon of glomerulosclerosis and of albuminuria.
1476-7058
362-365
Zanardo, Vincenzo
1ae8822c-b412-4958-84cb-0cc3d7a11ae8
Bertin, Martina
51f1ce44-b4ed-4f44-9e49-404ad577fb75
De Luca, Federico
079a076c-20af-4c1e-aa6f-cb82c7e126e6
Zaninotto, Martina
73f7ba5e-66bb-4d43-850d-a0af31e417de
Trevisanuto, Daniele
795bb19b-dd18-4084-bc23-ac676dd4fee9
Cosmi, Erich
a2b38fc6-371a-4741-bfb2-0b2f9b7f3bbc
Zanardo, Vincenzo
1ae8822c-b412-4958-84cb-0cc3d7a11ae8
Bertin, Martina
51f1ce44-b4ed-4f44-9e49-404ad577fb75
De Luca, Federico
079a076c-20af-4c1e-aa6f-cb82c7e126e6
Zaninotto, Martina
73f7ba5e-66bb-4d43-850d-a0af31e417de
Trevisanuto, Daniele
795bb19b-dd18-4084-bc23-ac676dd4fee9
Cosmi, Erich
a2b38fc6-371a-4741-bfb2-0b2f9b7f3bbc

Zanardo, Vincenzo, Bertin, Martina, De Luca, Federico, Zaninotto, Martina, Trevisanuto, Daniele and Cosmi, Erich (2015) Albuminuria and sodiuria in IUGR children. The Journal of Maternal-Fetal & Neonatal Medicine, 28 (3), 362-365. (doi:10.3109/14767058.2014.916684).

Record type: Article

Abstract

Objective: Intrauterine growth restriction (IUGR) is associated with hyperfiltration, glomerulosclerosis and albuminuria. Albuminuria may further lead to tubulointerstitial inflammation, fibrosis and tubular atrophy. The time at which this may occur is unknown. This study was designed to assess the relationship between glomerular and tubular damage in IUGR children. Methods: We enrolled 50 children, 25 IUGR, categorized by estimated fetal weight <10th percentile and umbilical artery pulsatility index >2 SD, and 25 appropriate for gestational age (AGA) controls at 18 months of age. We compared albuminuria among IUGR and AGA children, to assess the relationship between albuminuria and contemporary sodium and lysozyme excretion, as a measure of tubular damage. Results: The albumin-creatinine (mg/g) and sodium-creatinine (μM/L) ratios (3.12 and 441.3, versus 1.39 and 226.1 in AGA; p = 0.002 and p = 0.012, respectively) were significantly higher in the IUGR subjects compared with AGA children, and significantly correlated (rho = 0.593, p = 0.002). Conversely, urinary lysozyme was undetectable or in normal excretion range. Conclusions: Our results show glomerulosclerosis and albuminuria in IUGR children aged 18 months. Elevated sodium excretion in the absence of abnormal lysozymuria may represent a epiphenomenon of glomerulosclerosis and of albuminuria.

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e-pub ahead of print date: 22 May 2014
Published date: 11 February 2015

Identifiers

Local EPrints ID: 433373
URI: http://eprints.soton.ac.uk/id/eprint/433373
ISSN: 1476-7058
PURE UUID: 363c222b-9cfe-4c2a-b498-f82efb4fce17

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Date deposited: 15 Aug 2019 16:30
Last modified: 16 Mar 2024 03:24

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Contributors

Author: Vincenzo Zanardo
Author: Martina Bertin
Author: Federico De Luca
Author: Martina Zaninotto
Author: Daniele Trevisanuto
Author: Erich Cosmi

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