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Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets
Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and to examine the indications for the prescriptions recorded and whether there was contact with secondary care specialists on or around the time of the first antidepressant prescription. Methods and analysis All eligible CYP aged between 5 and 17 years in 1998-2017 from the QResearch primary care database will be included. Incidence and prevalence rates of any antidepressant prescription in each year will be calculated. We will examine four different antidepressant classes: selective serotonin reuptake inhibitors, tricyclic and related antidepressants, serotonin and norepinephrine reuptake inhibitors and other antidepressants, as well as for individual drugs. Linked primary and secondary care data (hospital episode statistics) in the year before and up to 6 months after the first antidepressant prescription will be examined for CYP whose first antidepressant prescription was in 2006-2017. Whether there were records of indications and being seen by psychiatric or paediatric specialists will be identified. Trends over time and differences by region, deprivation and ethnicity will be examined using Poisson regression. Discussion This large, population-based study will give an up-to-date picture of antidepressant prescribing in CYP and identify any variation. Understanding what indications are recorded when CYP are being prescribed antidepressants, and whether this was done in partnership with secondary care specialists, will provide evidence of whether appropriate guidelines are being followed.

1362-0347
129-133
Jack, Ruth H.
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Hollis, Chris
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Coupland, Carol
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Morriss, Richard
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Knaggs, Roger David
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Cipriani, Andrea
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Cortese, Samuele
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Hippisley-Cox, Julia
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Jack, Ruth H.
769e9c62-53e7-4d96-a583-0036a514d337
Hollis, Chris
fe8adc7a-cfcd-4966-b397-1dd22048bbc8
Coupland, Carol
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Morriss, Richard
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Knaggs, Roger David
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Cipriani, Andrea
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Cortese, Samuele
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Hippisley-Cox, Julia
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Jack, Ruth H., Hollis, Chris, Coupland, Carol, Morriss, Richard, Knaggs, Roger David, Cipriani, Andrea, Cortese, Samuele and Hippisley-Cox, Julia (2019) Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22 (3), 129-133. (doi:10.1136/ebmental-2019-300097).

Record type: Article

Abstract

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and to examine the indications for the prescriptions recorded and whether there was contact with secondary care specialists on or around the time of the first antidepressant prescription. Methods and analysis All eligible CYP aged between 5 and 17 years in 1998-2017 from the QResearch primary care database will be included. Incidence and prevalence rates of any antidepressant prescription in each year will be calculated. We will examine four different antidepressant classes: selective serotonin reuptake inhibitors, tricyclic and related antidepressants, serotonin and norepinephrine reuptake inhibitors and other antidepressants, as well as for individual drugs. Linked primary and secondary care data (hospital episode statistics) in the year before and up to 6 months after the first antidepressant prescription will be examined for CYP whose first antidepressant prescription was in 2006-2017. Whether there were records of indications and being seen by psychiatric or paediatric specialists will be identified. Trends over time and differences by region, deprivation and ethnicity will be examined using Poisson regression. Discussion This large, population-based study will give an up-to-date picture of antidepressant prescribing in CYP and identify any variation. Understanding what indications are recorded when CYP are being prescribed antidepressants, and whether this was done in partnership with secondary care specialists, will provide evidence of whether appropriate guidelines are being followed.

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Accepted/In Press date: 14 June 2019
e-pub ahead of print date: 28 June 2019
Published date: August 2019

Identifiers

Local EPrints ID: 433428
URI: http://eprints.soton.ac.uk/id/eprint/433428
ISSN: 1362-0347
PURE UUID: 5ff44881-98fd-4c0e-844d-67e7fe896453
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 22 Aug 2019 16:30
Last modified: 07 Oct 2020 02:07

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Contributors

Author: Ruth H. Jack
Author: Chris Hollis
Author: Carol Coupland
Author: Richard Morriss
Author: Roger David Knaggs
Author: Andrea Cipriani
Author: Samuele Cortese ORCID iD
Author: Julia Hippisley-Cox

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