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What is the role of α-blockers for medical expulsive therapy?: Results from a meta-analysis of 60 randomized trials and over 9500 patients

What is the role of α-blockers for medical expulsive therapy?: Results from a meta-analysis of 60 randomized trials and over 9500 patients
What is the role of α-blockers for medical expulsive therapy?: Results from a meta-analysis of 60 randomized trials and over 9500 patients

Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.

Adrenergic alpha-Antagonists/therapeutic use, Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Ureteral Calculi/drug therapy
0090-4295
5-16
Aboumarzouk, Omar M.
3c7e2433-638d-4378-9931-902fdc68acce
Jones, Patrick
d27beb5b-0e09-4ed5-89f0-6c62421c2397
Amer, Tarik
34b3aacc-a0bb-4f35-ae65-6808574e6c1f
Kotsiris, Dimitris
36a6c512-f83e-4b1f-88cb-a19f4ba1fa18
Emiliani, Esteban
aa8ffdc6-c992-48e4-8623-454e015a3812
Somani, Bhaskar
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Kallidonis, Panagiotis
85038e98-6c7a-487b-8b9d-839fabb84ada
Tailly, Thomas
c64befe9-ebc2-4b6b-acd6-ab72c7756384
Atis, Gohkan
b00aa9ef-54ef-4c20-904b-e026bfd211e0
Greco, Francesco
105d81e2-d2fc-4fd5-bef4-118f1d180675
Hruby, Stephan
6da08ac4-21c5-4e06-a05f-adeb0aa637b9
Alvarez, Mario
a38407ca-9cb8-4ee9-ae78-1e00306fc277
Al-Rumaihi, Khalid
ca25c130-12ee-4fd1-bc44-cb79ea70ef91
Shamsodini, Ahmad
abea2d1b-0afa-4ad5-b038-972e019c4a18
Al-Ansari, Abdulla
880fe476-bad3-4de2-9d83-20c5982d10a3
Shokeir, Ahmed
43ca4b76-b7db-4213-b481-81f6bb3fe338
Aboumarzouk, Omar M.
3c7e2433-638d-4378-9931-902fdc68acce
Jones, Patrick
d27beb5b-0e09-4ed5-89f0-6c62421c2397
Amer, Tarik
34b3aacc-a0bb-4f35-ae65-6808574e6c1f
Kotsiris, Dimitris
36a6c512-f83e-4b1f-88cb-a19f4ba1fa18
Emiliani, Esteban
aa8ffdc6-c992-48e4-8623-454e015a3812
Somani, Bhaskar
ab5fd1ce-02df-4b88-b25e-8ece396335d9
Kallidonis, Panagiotis
85038e98-6c7a-487b-8b9d-839fabb84ada
Tailly, Thomas
c64befe9-ebc2-4b6b-acd6-ab72c7756384
Atis, Gohkan
b00aa9ef-54ef-4c20-904b-e026bfd211e0
Greco, Francesco
105d81e2-d2fc-4fd5-bef4-118f1d180675
Hruby, Stephan
6da08ac4-21c5-4e06-a05f-adeb0aa637b9
Alvarez, Mario
a38407ca-9cb8-4ee9-ae78-1e00306fc277
Al-Rumaihi, Khalid
ca25c130-12ee-4fd1-bc44-cb79ea70ef91
Shamsodini, Ahmad
abea2d1b-0afa-4ad5-b038-972e019c4a18
Al-Ansari, Abdulla
880fe476-bad3-4de2-9d83-20c5982d10a3
Shokeir, Ahmed
43ca4b76-b7db-4213-b481-81f6bb3fe338

Aboumarzouk, Omar M., Jones, Patrick, Amer, Tarik, Kotsiris, Dimitris, Emiliani, Esteban, Somani, Bhaskar, Kallidonis, Panagiotis, Tailly, Thomas, Atis, Gohkan, Greco, Francesco, Hruby, Stephan, Alvarez, Mario, Al-Rumaihi, Khalid, Shamsodini, Ahmad, Al-Ansari, Abdulla and Shokeir, Ahmed (2018) What is the role of α-blockers for medical expulsive therapy?: Results from a meta-analysis of 60 randomized trials and over 9500 patients. Urology, 119, 5-16. (doi:10.1016/j.urology.2018.03.028).

Record type: Article

Abstract

Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.

Full text not available from this repository.

More information

Accepted/In Press date: 22 March 2018
e-pub ahead of print date: 4 April 2018
Published date: September 2018
Additional Information: Copyright © 2018. Published by Elsevier Inc.
Keywords: Adrenergic alpha-Antagonists/therapeutic use, Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Ureteral Calculi/drug therapy

Identifiers

Local EPrints ID: 433448
URI: http://eprints.soton.ac.uk/id/eprint/433448
ISSN: 0090-4295
PURE UUID: 935461d3-021d-49af-aa26-fd8bcb563378

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Date deposited: 22 Aug 2019 16:30
Last modified: 22 Aug 2019 16:30

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Contributors

Author: Omar M. Aboumarzouk
Author: Patrick Jones
Author: Tarik Amer
Author: Dimitris Kotsiris
Author: Esteban Emiliani
Author: Bhaskar Somani
Author: Panagiotis Kallidonis
Author: Thomas Tailly
Author: Gohkan Atis
Author: Francesco Greco
Author: Stephan Hruby
Author: Mario Alvarez
Author: Khalid Al-Rumaihi
Author: Ahmad Shamsodini
Author: Abdulla Al-Ansari
Author: Ahmed Shokeir

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