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Gut microbiota and osteoarthritis management: an expert consensus of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

Gut microbiota and osteoarthritis management: an expert consensus of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
Gut microbiota and osteoarthritis management: an expert consensus of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and the need to define preventive and therapeutic interventions targeting the modifiable components of OA, an expert working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) to review the potential contribution of GMB to OA. Such a contribution is supported by observational or dietary intervention studies in animal models of OA and in humans. In addition, several well-recognized risk factors of OA interact with GMB. Lastly, GMB is a critical determinant of drug metabolism and bioavailability and may influence the response to OA medications. Further research targeting GMB or its metabolites is needed to move the field of OA from symptomatic management to individualized interventions targeting its pathogenesis.
1568-1637
1-8
Biver, Emmanuel
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Berenbaum, Francis
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Valdes, Ana M.
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de Carvalho, Islene Araujo
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Bindels, Laure B.
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Brandi, Maria Luisa
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Calder, Philip
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Castronovo, Vincenzo
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Cavalier, Etienne
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Cherubini, Antonio
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Cooper, Cyrus
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Dennison, Elaine
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Franceschi, Claudio
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Fuggle, Nicholas
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Laslop, Andrea
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Miossec, Pierre
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Thomas, Thierry
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Tuzun, Sansin
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Veronese, Nicola
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Vlaskovska, Mila
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Reginster, Jean-Yves
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Rizzoli, René
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Biver, Emmanuel
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Berenbaum, Francis
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Valdes, Ana M.
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de Carvalho, Islene Araujo
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Bindels, Laure B.
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Brandi, Maria Luisa
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Calder, Philip
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Castronovo, Vincenzo
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Cavalier, Etienne
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Cherubini, Antonio
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Cooper, Cyrus
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Dennison, Elaine
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Franceschi, Claudio
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Fuggle, Nicholas
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Laslop, Andrea
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Miossec, Pierre
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Thomas, Thierry
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Tuzun, Sansin
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Veronese, Nicola
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Vlaskovska, Mila
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Reginster, Jean-Yves
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Rizzoli, René
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Biver, Emmanuel, Berenbaum, Francis, Valdes, Ana M., de Carvalho, Islene Araujo, Bindels, Laure B., Brandi, Maria Luisa, Calder, Philip, Castronovo, Vincenzo, Cavalier, Etienne, Cherubini, Antonio, Cooper, Cyrus, Dennison, Elaine, Franceschi, Claudio, Fuggle, Nicholas, Laslop, Andrea, Miossec, Pierre, Thomas, Thierry, Tuzun, Sansin, Veronese, Nicola, Vlaskovska, Mila, Reginster, Jean-Yves and Rizzoli, René (2019) Gut microbiota and osteoarthritis management: an expert consensus of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Ageing Research Reviews, 55, 1-8, [100946]. (doi:10.1016/j.arr.2019.100946).

Record type: Article

Abstract

The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and the need to define preventive and therapeutic interventions targeting the modifiable components of OA, an expert working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) to review the potential contribution of GMB to OA. Such a contribution is supported by observational or dietary intervention studies in animal models of OA and in humans. In addition, several well-recognized risk factors of OA interact with GMB. Lastly, GMB is a critical determinant of drug metabolism and bioavailability and may influence the response to OA medications. Further research targeting GMB or its metabolites is needed to move the field of OA from symptomatic management to individualized interventions targeting its pathogenesis.

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ESCEO OA GMB 05.07.2019_v5.3 R1 - Accepted Manuscript
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Accepted/In Press date: 16 August 2019
e-pub ahead of print date: 19 August 2019
Published date: November 2019

Identifiers

Local EPrints ID: 433477
URI: http://eprints.soton.ac.uk/id/eprint/433477
ISSN: 1568-1637
PURE UUID: 112e12be-f14a-4379-a683-1613e6ee72d2
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961

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Date deposited: 23 Aug 2019 16:30
Last modified: 11 Mar 2021 02:35

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Contributors

Author: Emmanuel Biver
Author: Francis Berenbaum
Author: Ana M. Valdes
Author: Islene Araujo de Carvalho
Author: Laure B. Bindels
Author: Maria Luisa Brandi
Author: Philip Calder ORCID iD
Author: Vincenzo Castronovo
Author: Etienne Cavalier
Author: Antonio Cherubini
Author: Cyrus Cooper ORCID iD
Author: Elaine Dennison ORCID iD
Author: Claudio Franceschi
Author: Nicholas Fuggle
Author: Andrea Laslop
Author: Pierre Miossec
Author: Thierry Thomas
Author: Sansin Tuzun
Author: Nicola Veronese
Author: Mila Vlaskovska
Author: Jean-Yves Reginster
Author: René Rizzoli

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