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Experimental medicine models in generalized anxiety disorder and social anxiety disorder

Experimental medicine models in generalized anxiety disorder and social anxiety disorder
Experimental medicine models in generalized anxiety disorder and social anxiety disorder

Numerous pharmacological and psychological approaches are efficacious in patients with generalized anxiety disorder (GAD) and social anxiety disorder (SAD), though some patients do not respond to treatment and others relapse despite continuing with interventions that were initially beneficial. Other patients respond but stop treatment because of unwanted effects including sexual dysfunction, emotional blunting, and weight gain. There is much need for novel interventions with greater overall effectiveness and enhanced acceptability when compared with current treatments or with particular effectiveness in specific patient groups. “Experimental medicine” studies conducted in healthy subjects provide a “proof-of-concept” approach for determining whether to progress to pivotal efficacy studies, thereby potentially reducing delays in translating innovations into clinical practice. Examples of such studies include inhalation of air “enriched” with 7.5% carbon dioxide, which mirrors the subjective, autonomic, and cognitive features of GAD, and administration of testosterone or oxytocin, which respectively target the social avoidance and emotion processing biases of SAD.

Carbon dioxide inhalation, Experimental medicine, Generalized anxiety disorder, Oxytocin, Pharmacotherapy, Social anxiety disorder, Testosterone, Translation
1569-7339
363-374
Elsevier B.V.
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Abou-Aisha, Ayman
514d9775-8070-485f-b59d-84b4a23c0d56
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Abou-Aisha, Ayman
514d9775-8070-485f-b59d-84b4a23c0d56

Baldwin, David S. and Abou-Aisha, Ayman (2019) Experimental medicine models in generalized anxiety disorder and social anxiety disorder. In, Handbook of Behavioral Neuroscience. (Handbook of Behavioral Neuroscience, 29) Elsevier B.V., pp. 363-374. (doi:10.1016/B978-0-12-803161-2.00025-4).

Record type: Book Section

Abstract

Numerous pharmacological and psychological approaches are efficacious in patients with generalized anxiety disorder (GAD) and social anxiety disorder (SAD), though some patients do not respond to treatment and others relapse despite continuing with interventions that were initially beneficial. Other patients respond but stop treatment because of unwanted effects including sexual dysfunction, emotional blunting, and weight gain. There is much need for novel interventions with greater overall effectiveness and enhanced acceptability when compared with current treatments or with particular effectiveness in specific patient groups. “Experimental medicine” studies conducted in healthy subjects provide a “proof-of-concept” approach for determining whether to progress to pivotal efficacy studies, thereby potentially reducing delays in translating innovations into clinical practice. Examples of such studies include inhalation of air “enriched” with 7.5% carbon dioxide, which mirrors the subjective, autonomic, and cognitive features of GAD, and administration of testosterone or oxytocin, which respectively target the social avoidance and emotion processing biases of SAD.

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More information

e-pub ahead of print date: 17 June 2019
Keywords: Carbon dioxide inhalation, Experimental medicine, Generalized anxiety disorder, Oxytocin, Pharmacotherapy, Social anxiety disorder, Testosterone, Translation

Identifiers

Local EPrints ID: 433579
URI: http://eprints.soton.ac.uk/id/eprint/433579
ISSN: 1569-7339
PURE UUID: 43ec32dd-cb36-447b-88da-c300e25d884b
ORCID for David S. Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

Catalogue record

Date deposited: 28 Aug 2019 16:30
Last modified: 10 Nov 2021 02:47

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Author: Ayman Abou-Aisha

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