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Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease

Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease
Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease
Neuroinflammation, as defined by the activation of microglia and astrocytes, has emerged in the last years as a key element of the pathogenesis of neurodegenerative diseases based on genetic findings and preclinical and human studies. This has raised the need for new methodologies to assess and follow glial activation in patients, prompting the development of PET ligands for molecular imaging of glial cells and novel structural MRI and DTI tools leading to a multimodal approach.
The present review describes the recent advancements in microglia and astrocyte biology in the context of health, ageing and Alzheimer’s disease, the most common dementia worldwide. The review further delves in molecular imaging discussing the challenges associated with past and present targets, including conflicting findings, and finally presenting novel methodologies currently explored to improve our in vivo knowledge of the neuroinflammatory patterns in Alzheimer’s disease. With glial cell activation as a potential therapeutic target in neurodegenerative diseases, the translational research between cell biologists, chemists, physicists, radiologists and neurologists should be strengthened.
TSPO, microglia, astrocyte, Alzheimer’s disease, PET, MRI
1619-7070
1-17
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Gerhard, Alexander
50246974-7989-4bc2-ab4e-56a3b3927046
Rodriguez-Vieitez, Elena
65da0c32-2df7-493f-adec-da8903122c61
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Gerhard, Alexander
50246974-7989-4bc2-ab4e-56a3b3927046
Rodriguez-Vieitez, Elena
65da0c32-2df7-493f-adec-da8903122c61

Boche, Delphine, Gerhard, Alexander and Rodriguez-Vieitez, Elena (2019) Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 1-17. (doi:10.1007/s00259-019-04462-w).

Record type: Review

Abstract

Neuroinflammation, as defined by the activation of microglia and astrocytes, has emerged in the last years as a key element of the pathogenesis of neurodegenerative diseases based on genetic findings and preclinical and human studies. This has raised the need for new methodologies to assess and follow glial activation in patients, prompting the development of PET ligands for molecular imaging of glial cells and novel structural MRI and DTI tools leading to a multimodal approach.
The present review describes the recent advancements in microglia and astrocyte biology in the context of health, ageing and Alzheimer’s disease, the most common dementia worldwide. The review further delves in molecular imaging discussing the challenges associated with past and present targets, including conflicting findings, and finally presenting novel methodologies currently explored to improve our in vivo knowledge of the neuroinflammatory patterns in Alzheimer’s disease. With glial cell activation as a potential therapeutic target in neurodegenerative diseases, the translational research between cell biologists, chemists, physicists, radiologists and neurologists should be strengthened.

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EJNM-D-19-00703_R1 - Accepted Manuscript
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Boche2019_Article_ProspectsAndChallengesOfImagin - Version of Record
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More information

Accepted/In Press date: 22 July 2019
e-pub ahead of print date: 8 August 2019
Keywords: TSPO, microglia, astrocyte, Alzheimer’s disease, PET, MRI

Identifiers

Local EPrints ID: 433645
URI: http://eprints.soton.ac.uk/id/eprint/433645
ISSN: 1619-7070
PURE UUID: b85a820c-884b-4bbb-bd71-fd8c700ba779
ORCID for Delphine Boche: ORCID iD orcid.org/0000-0002-5884-130X

Catalogue record

Date deposited: 28 Aug 2019 16:31
Last modified: 26 Nov 2021 06:30

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Contributors

Author: Delphine Boche ORCID iD
Author: Alexander Gerhard
Author: Elena Rodriguez-Vieitez

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