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HORIZONS protocol: a UK prospective cohort study to explore recovery of health and well-being in adults diagnosed with cancer

HORIZONS protocol: a UK prospective cohort study to explore recovery of health and well-being in adults diagnosed with cancer
HORIZONS protocol: a UK prospective cohort study to explore recovery of health and well-being in adults diagnosed with cancer

INTRODUCTION: Understanding the impact of cancer and its treatment on people's everyday lives will help prepare people for what to expect, enable health professionals to predict likely recovery trajectories and shape care management according to needs. HORIZONS will recruit people awaiting treatment and follow them up at regular intervals to assess recovery of health and well-being. RESEARCH QUESTIONS: What impact does cancer diagnosis and treatment have on people's lives in the short, medium and long term? What are people's health and well-being outcomes, experiences and self-management activities over time across different cancer types and what influences these? How do people connect with and relate to others in mobilising resources that enable them to self-manage the consequences of cancer and treatment? METHODS AND ANALYSIS: HORIZONS is a multicentre, prospective cohort study exploring recovery of health and well-being in 3000 people diagnosed with breast cancer (<50 years), non-Hodgkin's lymphoma or gynaecological cancer. Recruitment will take place across National Health Service (NHS) sites in the UK between September 2016 and March 2019, before primary treatment starts. Participants will be identified through clinical teams and invited to complete questionnaires including assessments of quality of life, symptoms and functioning (Quality of Life in Adult Cancer Survivors; European Organisation for Research and Treatment Consortium Core quality of life questionnaire, EORTC-QLQ-C30), health status (EuroQol-5 dimensions, EQ-5D), self-efficacy, social support, social networks and lifestyle. Clinical data will also be collected. Descriptive statistics will characterise outcomes. Changes over time will be investigated. Factors that may influence recovery and self-management will be included in regression models to determine which influence health and well-being and self-management. ETHICS AND DISSEMINATION: Ethics and Health Research Authority approvals granted (IRAS Project ID: 202342, REC reference number 16/NW/0425). Adopted onto the National Institute for Health Research Clinical Research Network portfolio. We will engage with our Scientific Advisory Board, Tumour Specific Expert Panels, User Reference Group, Macmillan and the University of Southampton to ensure maximum publicity and benefit.

cancer survivorship, cohort, longitudinal, quality of life, recovery
2044-6055
1-8
Foster, Claire
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Calman, Lynn
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Richardson, Alison
3db30680-aa47-43a5-b54d-62d10ece17b7
May, Carl R.
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Rogers, Anne
105eeebc-1899-4850-950e-385a51738eb7
Smith, Peter W.
961a01a3-bf4c-43ca-9599-5be4fd5d3940
Foster, Claire
00786ac1-bd47-4aeb-a0e2-40e058695b73
Calman, Lynn
9ae254eb-74a7-4906-9eb4-62ad99f058c1
Richardson, Alison
3db30680-aa47-43a5-b54d-62d10ece17b7
May, Carl R.
17697f8d-98f6-40d3-9cc0-022f04009ae4
Rogers, Anne
105eeebc-1899-4850-950e-385a51738eb7
Smith, Peter W.
961a01a3-bf4c-43ca-9599-5be4fd5d3940

Foster, Claire, Calman, Lynn, Richardson, Alison, May, Carl R., Rogers, Anne and Smith, Peter W. (2019) HORIZONS protocol: a UK prospective cohort study to explore recovery of health and well-being in adults diagnosed with cancer. BMJ Open, 9 (7), 1-8, [e029662]. (doi:10.1136/bmjopen-2019-029662).

Record type: Article

Abstract

INTRODUCTION: Understanding the impact of cancer and its treatment on people's everyday lives will help prepare people for what to expect, enable health professionals to predict likely recovery trajectories and shape care management according to needs. HORIZONS will recruit people awaiting treatment and follow them up at regular intervals to assess recovery of health and well-being. RESEARCH QUESTIONS: What impact does cancer diagnosis and treatment have on people's lives in the short, medium and long term? What are people's health and well-being outcomes, experiences and self-management activities over time across different cancer types and what influences these? How do people connect with and relate to others in mobilising resources that enable them to self-manage the consequences of cancer and treatment? METHODS AND ANALYSIS: HORIZONS is a multicentre, prospective cohort study exploring recovery of health and well-being in 3000 people diagnosed with breast cancer (<50 years), non-Hodgkin's lymphoma or gynaecological cancer. Recruitment will take place across National Health Service (NHS) sites in the UK between September 2016 and March 2019, before primary treatment starts. Participants will be identified through clinical teams and invited to complete questionnaires including assessments of quality of life, symptoms and functioning (Quality of Life in Adult Cancer Survivors; European Organisation for Research and Treatment Consortium Core quality of life questionnaire, EORTC-QLQ-C30), health status (EuroQol-5 dimensions, EQ-5D), self-efficacy, social support, social networks and lifestyle. Clinical data will also be collected. Descriptive statistics will characterise outcomes. Changes over time will be investigated. Factors that may influence recovery and self-management will be included in regression models to determine which influence health and well-being and self-management. ETHICS AND DISSEMINATION: Ethics and Health Research Authority approvals granted (IRAS Project ID: 202342, REC reference number 16/NW/0425). Adopted onto the National Institute for Health Research Clinical Research Network portfolio. We will engage with our Scientific Advisory Board, Tumour Specific Expert Panels, User Reference Group, Macmillan and the University of Southampton to ensure maximum publicity and benefit.

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Accepted/In Press date: 24 June 2019
Published date: 26 July 2019
Keywords: cancer survivorship, cohort, longitudinal, quality of life, recovery

Identifiers

Local EPrints ID: 433673
URI: http://eprints.soton.ac.uk/id/eprint/433673
ISSN: 2044-6055
PURE UUID: bc5f4abe-f2e1-4627-ab35-375861ea438c
ORCID for Claire Foster: ORCID iD orcid.org/0000-0002-4703-8378
ORCID for Lynn Calman: ORCID iD orcid.org/0000-0002-9964-6017
ORCID for Alison Richardson: ORCID iD orcid.org/0000-0003-3127-5755
ORCID for Carl R. May: ORCID iD orcid.org/0000-0002-0451-2690
ORCID for Peter W. Smith: ORCID iD orcid.org/0000-0003-4423-5410

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Date deposited: 30 Aug 2019 16:30
Last modified: 07 Oct 2020 02:00

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Contributors

Author: Claire Foster ORCID iD
Author: Lynn Calman ORCID iD
Author: Carl R. May ORCID iD
Author: Anne Rogers
Author: Peter W. Smith ORCID iD

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