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Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation

Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation
Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation
We developed a facile one-pot procedure for the synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thione under ultrasonic irradiation. The method is based on a three components reaction of aldehydes, ketones, and thiourea under basic conditions affording isolated yields of up to 95% within a reaction time of 30–90 min.
0039-7911
A. Abbass, Shymaa
abf600e0-11f7-4c3c-9334-9c0dd26004ca
Moustafa, Gamal A.I.
1a452cdc-4856-4243-9864-b391fb115f07
A. Hassan, Heba
dc0b4d2b-8610-45b6-9e17-bb3c7f4e6285
El-Din A. Abuo-Rahma, Gamal
a8a7c16a-637b-4f9a-b2b4-ae244847f14a
A. Abbass, Shymaa
abf600e0-11f7-4c3c-9334-9c0dd26004ca
Moustafa, Gamal A.I.
1a452cdc-4856-4243-9864-b391fb115f07
A. Hassan, Heba
dc0b4d2b-8610-45b6-9e17-bb3c7f4e6285
El-Din A. Abuo-Rahma, Gamal
a8a7c16a-637b-4f9a-b2b4-ae244847f14a

A. Abbass, Shymaa, Moustafa, Gamal A.I., A. Hassan, Heba and El-Din A. Abuo-Rahma, Gamal (2019) Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation. Synthetic Communications, 49 (21). (doi:10.1080/00397911.2019.1652759).

Record type: Article

Abstract

We developed a facile one-pot procedure for the synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thione under ultrasonic irradiation. The method is based on a three components reaction of aldehydes, ketones, and thiourea under basic conditions affording isolated yields of up to 95% within a reaction time of 30–90 min.

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Accepted/In Press date: 2 August 2019
Published date: 12 August 2019

Identifiers

Local EPrints ID: 433767
URI: http://eprints.soton.ac.uk/id/eprint/433767
ISSN: 0039-7911
PURE UUID: 1ed88173-b015-4e49-91a3-3f7146d4d426
ORCID for Gamal A.I. Moustafa: ORCID iD orcid.org/0000-0002-9940-0033

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Date deposited: 03 Sep 2019 16:30
Last modified: 16 Mar 2024 04:40

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Contributors

Author: Shymaa A. Abbass
Author: Heba A. Hassan
Author: Gamal El-Din A. Abuo-Rahma

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