The Collaborative Ocular Tuberculosis Study (COTS)-1: a multinational description of the spectrum of choroidal involvement in 245 patients with tubercular uveitis

Agrawal, Rupesh, Gunasekeran, Dinesh Visva, Agarwal, Aniruddha, Carreño, Ester, Aggarwal, Kanika, Gupta, Bhaskar, Raje, Dhananjay, Murthy, Somasheila I., Westcott, Mark, Chee, Soon Phaik, McCluskey, Peter, Ling, Ho Su, Teoh, Stephen, Cimino, Luca, Biswas, Jyotirmay, Narain, Shishir, Agarwal, Manisha, Mahendradas, Padmamalini, Khairallah, Moncef, Jones, Nicholas, Tugal-Tutkun, Ilknur, Babu, Kalpana, Basu, Soumayava, Lee, Richard, Al-Dhibi, Hassan, Bodaghi, Bahram, Invernizzi, Alessandro, Goldstein, Debra A., Herbort, Carl P., Barisani-Asenbauer, Talin, González-López, Julio J., Androudi, Sofia, Bansal, Reema, Moharana, Bruttendu, Mahajan, Sarakshi, Esposti, Simona, Tasiopoulou, Anastasia, Nadarajah, Sengal, Agarwal, Mamta, Abraham, Sharanya, Vala, Ruchi, Lord, Joanne, Singh, Ramandeep, Sharma, Aman, Sharma, Kusum, Zierhut, Manfred, Kon, Onn Min, Kempen, John, Cunningham, Emmett T., Rousselot, Andres, Nguyen, Quan Dong, Pavesio, Carlos and Gupta, Vishali (2018) The Collaborative Ocular Tuberculosis Study (COTS)-1: a multinational description of the spectrum of choroidal involvement in 245 patients with tubercular uveitis. Ocular Immunology and Inflammation, 1-11. (doi:10.1080/09273948.2018.1489061).

Abstract

Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

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Contributors

Author: Joanne Lord

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