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The Collaborative Ocular Tuberculosis Study (COTS)-1: a multinational description of the spectrum of choroidal involvement in 245 patients with tubercular uveitis

The Collaborative Ocular Tuberculosis Study (COTS)-1: a multinational description of the spectrum of choroidal involvement in 245 patients with tubercular uveitis
The Collaborative Ocular Tuberculosis Study (COTS)-1: a multinational description of the spectrum of choroidal involvement in 245 patients with tubercular uveitis

Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

Anti-tubercular therapy, choroiditis, ocular, tuberculosis, uveitis
0927-3948
1-11
Agrawal, Rupesh
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Gunasekeran, Dinesh Visva
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Agarwal, Aniruddha
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Carreño, Ester
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Aggarwal, Kanika
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Gupta, Bhaskar
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Murthy, Somasheila I.
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Westcott, Mark
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Chee, Soon Phaik
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McCluskey, Peter
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Teoh, Stephen
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Khairallah, Moncef
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Jones, Nicholas
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Lee, Richard
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Al-Dhibi, Hassan
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Bodaghi, Bahram
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Invernizzi, Alessandro
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Goldstein, Debra A.
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Tasiopoulou, Anastasia
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Nadarajah, Sengal
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Agarwal, Mamta
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Abraham, Sharanya
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Vala, Ruchi
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Lord, Joanne
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Singh, Ramandeep
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Sharma, Aman
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Sharma, Kusum
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Zierhut, Manfred
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Kon, Onn Min
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Kempen, John
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Cunningham, Emmett T.
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Rousselot, Andres
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Nguyen, Quan Dong
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Pavesio, Carlos
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Gupta, Vishali
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Agrawal, Rupesh
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Gunasekeran, Dinesh Visva
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Agarwal, Aniruddha
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Carreño, Ester
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Aggarwal, Kanika
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Gupta, Bhaskar
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Raje, Dhananjay
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Murthy, Somasheila I.
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Westcott, Mark
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Chee, Soon Phaik
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McCluskey, Peter
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Ling, Ho Su
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Teoh, Stephen
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Cimino, Luca
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Biswas, Jyotirmay
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Narain, Shishir
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Agarwal, Manisha
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Mahendradas, Padmamalini
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Khairallah, Moncef
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Jones, Nicholas
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Tugal-Tutkun, Ilknur
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Babu, Kalpana
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Basu, Soumayava
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Lee, Richard
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Al-Dhibi, Hassan
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Bodaghi, Bahram
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Invernizzi, Alessandro
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Goldstein, Debra A.
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Herbort, Carl P.
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Barisani-Asenbauer, Talin
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González-López, Julio J.
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Androudi, Sofia
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Bansal, Reema
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Moharana, Bruttendu
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Mahajan, Sarakshi
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Esposti, Simona
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Tasiopoulou, Anastasia
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Nadarajah, Sengal
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Agarwal, Mamta
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Abraham, Sharanya
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Vala, Ruchi
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Lord, Joanne
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Singh, Ramandeep
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Sharma, Aman
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Sharma, Kusum
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Zierhut, Manfred
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Kon, Onn Min
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Kempen, John
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Cunningham, Emmett T.
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Rousselot, Andres
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Nguyen, Quan Dong
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Pavesio, Carlos
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Gupta, Vishali
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Agrawal, Rupesh, Gunasekeran, Dinesh Visva, Agarwal, Aniruddha, Carreño, Ester, Aggarwal, Kanika, Gupta, Bhaskar, Raje, Dhananjay, Murthy, Somasheila I., Westcott, Mark, Chee, Soon Phaik, McCluskey, Peter, Ling, Ho Su, Teoh, Stephen, Cimino, Luca, Biswas, Jyotirmay, Narain, Shishir, Agarwal, Manisha, Mahendradas, Padmamalini, Khairallah, Moncef, Jones, Nicholas, Tugal-Tutkun, Ilknur, Babu, Kalpana, Basu, Soumayava, Lee, Richard, Al-Dhibi, Hassan, Bodaghi, Bahram, Invernizzi, Alessandro, Goldstein, Debra A., Herbort, Carl P., Barisani-Asenbauer, Talin, González-López, Julio J., Androudi, Sofia, Bansal, Reema, Moharana, Bruttendu, Mahajan, Sarakshi, Esposti, Simona, Tasiopoulou, Anastasia, Nadarajah, Sengal, Agarwal, Mamta, Abraham, Sharanya, Vala, Ruchi, Lord, Joanne, Singh, Ramandeep, Sharma, Aman, Sharma, Kusum, Zierhut, Manfred, Kon, Onn Min, Kempen, John, Cunningham, Emmett T., Rousselot, Andres, Nguyen, Quan Dong, Pavesio, Carlos and Gupta, Vishali (2018) The Collaborative Ocular Tuberculosis Study (COTS)-1: a multinational description of the spectrum of choroidal involvement in 245 patients with tubercular uveitis. Ocular Immunology and Inflammation, 1-11. (doi:10.1080/09273948.2018.1489061).

Record type: Article

Abstract

Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

Full text not available from this repository.

More information

Accepted/In Press date: 1 January 2018
e-pub ahead of print date: 29 August 2018
Keywords: Anti-tubercular therapy, choroiditis, ocular, tuberculosis, uveitis

Identifiers

Local EPrints ID: 433795
URI: http://eprints.soton.ac.uk/id/eprint/433795
ISSN: 0927-3948
PURE UUID: 78a12717-c69e-446e-ba32-60e6ac117245
ORCID for Joanne Lord: ORCID iD orcid.org/0000-0003-1086-1624

Catalogue record

Date deposited: 04 Sep 2019 16:30
Last modified: 17 Dec 2019 01:33

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Contributors

Author: Rupesh Agrawal
Author: Dinesh Visva Gunasekeran
Author: Aniruddha Agarwal
Author: Ester Carreño
Author: Kanika Aggarwal
Author: Bhaskar Gupta
Author: Dhananjay Raje
Author: Somasheila I. Murthy
Author: Mark Westcott
Author: Soon Phaik Chee
Author: Peter McCluskey
Author: Ho Su Ling
Author: Stephen Teoh
Author: Luca Cimino
Author: Jyotirmay Biswas
Author: Shishir Narain
Author: Manisha Agarwal
Author: Padmamalini Mahendradas
Author: Moncef Khairallah
Author: Nicholas Jones
Author: Ilknur Tugal-Tutkun
Author: Kalpana Babu
Author: Soumayava Basu
Author: Richard Lee
Author: Hassan Al-Dhibi
Author: Bahram Bodaghi
Author: Alessandro Invernizzi
Author: Debra A. Goldstein
Author: Carl P. Herbort
Author: Talin Barisani-Asenbauer
Author: Julio J. González-López
Author: Sofia Androudi
Author: Reema Bansal
Author: Bruttendu Moharana
Author: Sarakshi Mahajan
Author: Simona Esposti
Author: Anastasia Tasiopoulou
Author: Sengal Nadarajah
Author: Mamta Agarwal
Author: Sharanya Abraham
Author: Ruchi Vala
Author: Joanne Lord ORCID iD
Author: Ramandeep Singh
Author: Aman Sharma
Author: Kusum Sharma
Author: Manfred Zierhut
Author: Onn Min Kon
Author: John Kempen
Author: Emmett T. Cunningham
Author: Andres Rousselot
Author: Quan Dong Nguyen
Author: Carlos Pavesio
Author: Vishali Gupta

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