Association between antipsychotic medication use and diabetes
Association between antipsychotic medication use and diabetes
Purpose of Review
The prevalence of diabetes is 2–3-fold higher in people with severe mental illness than the general population. There are concerns that antipsychotics increase the risk of diabetes. This review will examine the latest epidemiological studies linking antipsychotics and diabetes, as well as the mechanisms underlying the association and the clinical implications to minimise the impact of antipsychotics on metabolic health.
Recent Findings
Although there is an increased risk of diabetes in people with first-episode psychosis, the prevalence increases rapidly after antipsychotics are started. Antipsychotics likely increase the risk of diabetes through weight gain and directly by adversely affecting insulin sensitivity and secretion.
Summary
It is important to implement measures to prevent diabetes, to screen for diabetes to ensure prompt diagnosis and to provide effective diabetes care. Further research is needed to understand how antipsychotics cause diabetes and to improve the clinical management of diabetes in people with severe mental illness.
Holt, Richard I. G.
d54202e1-fcf6-4a17-a320-9f32d7024393
October 2019
Holt, Richard I. G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Holt, Richard I. G.
(2019)
Association between antipsychotic medication use and diabetes.
Current Diabetes Reports, 19 (10), [96].
(doi:10.1007/s11892-019-1220-8).
Abstract
Purpose of Review
The prevalence of diabetes is 2–3-fold higher in people with severe mental illness than the general population. There are concerns that antipsychotics increase the risk of diabetes. This review will examine the latest epidemiological studies linking antipsychotics and diabetes, as well as the mechanisms underlying the association and the clinical implications to minimise the impact of antipsychotics on metabolic health.
Recent Findings
Although there is an increased risk of diabetes in people with first-episode psychosis, the prevalence increases rapidly after antipsychotics are started. Antipsychotics likely increase the risk of diabetes through weight gain and directly by adversely affecting insulin sensitivity and secretion.
Summary
It is important to implement measures to prevent diabetes, to screen for diabetes to ensure prompt diagnosis and to provide effective diabetes care. Further research is needed to understand how antipsychotics cause diabetes and to improve the clinical management of diabetes in people with severe mental illness.
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Accepted/In Press date: 31 July 2019
e-pub ahead of print date: 2 September 2019
Published date: October 2019
Identifiers
Local EPrints ID: 433917
URI: http://eprints.soton.ac.uk/id/eprint/433917
ISSN: 1534-4827
PURE UUID: ea2b84c0-de95-4bde-acc9-5406245d462d
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Date deposited: 06 Sep 2019 16:30
Last modified: 17 Mar 2024 02:52
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