The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Auditory temporal acuity improves with age in the male mouse auditory thalamus: a role for perineuronal nets?

Auditory temporal acuity improves with age in the male mouse auditory thalamus: a role for perineuronal nets?
Auditory temporal acuity improves with age in the male mouse auditory thalamus: a role for perineuronal nets?
The ability to perceive and interpret environmental sound accurately is conserved across many species and is fundamental for understanding communication via vocalisations. Auditory acuity and temporally-controlled neuronal firing underpin this ability. Deterioration in neuronal firing precision likely contributes to poorer hearing performance, yet the role of neural processing by key nuclei in the central auditory pathways is not fully understood. Here, we record from the auditory thalamus (medial geniculate body, (MGB)) of young and middle-aged, normally-hearing male CBA\Ca mice.
We report changes in temporal processing of auditory stimuli, with neurons recorded from ventral and medial MGB subdivisions of older animals more likely to synchronise to rapid temporally varying stimuli. MGB subdivisions also showed increased probability of neuronal firing and shorter response latencies to clicks in older animals. Histological investigation of neuronal extracellular specialisations, perineuronal nets (PNNs) and axonal coats, in the MGB identified greater organisation of PNNs around MGB neurons and the presence of axonal coats within older animals. This supports the observation that neural responses recorded from ventral and medial MGB of older mice were more likely to synchronise to temporally-varying stimuli presented at faster repetition rates than those recorded from young adult animals. These changes are observed in animals with normal hearing thresholds, confirming that neural-processing differs between the MGB sub-divisions and such processing is associated with age-related changes to PNNs. Understanding these age-related changes and how they occur has important implications for the design of effective therapeutic interventions to improve speech intelligibility into later life.
0360-4012
Quraishe, Shmma
cfc3aed4-f120-41aa-9127-0fc26c657ad2
Newman, Tracey
322290cb-2e9c-445d-a047-00b1bea39a25
Anderson, Lucy
67943e90-8cc8-4fe4-baf2-eb06ecad8ec0
Quraishe, Shmma
cfc3aed4-f120-41aa-9127-0fc26c657ad2
Newman, Tracey
322290cb-2e9c-445d-a047-00b1bea39a25
Anderson, Lucy
67943e90-8cc8-4fe4-baf2-eb06ecad8ec0

Quraishe, Shmma, Newman, Tracey and Anderson, Lucy (2019) Auditory temporal acuity improves with age in the male mouse auditory thalamus: a role for perineuronal nets? Journal of Neuroscience Research. (doi:10.1002/jnr.24537).

Record type: Article

Abstract

The ability to perceive and interpret environmental sound accurately is conserved across many species and is fundamental for understanding communication via vocalisations. Auditory acuity and temporally-controlled neuronal firing underpin this ability. Deterioration in neuronal firing precision likely contributes to poorer hearing performance, yet the role of neural processing by key nuclei in the central auditory pathways is not fully understood. Here, we record from the auditory thalamus (medial geniculate body, (MGB)) of young and middle-aged, normally-hearing male CBA\Ca mice.
We report changes in temporal processing of auditory stimuli, with neurons recorded from ventral and medial MGB subdivisions of older animals more likely to synchronise to rapid temporally varying stimuli. MGB subdivisions also showed increased probability of neuronal firing and shorter response latencies to clicks in older animals. Histological investigation of neuronal extracellular specialisations, perineuronal nets (PNNs) and axonal coats, in the MGB identified greater organisation of PNNs around MGB neurons and the presence of axonal coats within older animals. This supports the observation that neural responses recorded from ventral and medial MGB of older mice were more likely to synchronise to temporally-varying stimuli presented at faster repetition rates than those recorded from young adult animals. These changes are observed in animals with normal hearing thresholds, confirming that neural-processing differs between the MGB sub-divisions and such processing is associated with age-related changes to PNNs. Understanding these age-related changes and how they occur has important implications for the design of effective therapeutic interventions to improve speech intelligibility into later life.

Text
jnr-2019-Apr-8057.R2_Proof_R2 - Accepted Manuscript
Download (3MB)

More information

Accepted/In Press date: 15 September 2019
e-pub ahead of print date: 27 September 2019

Identifiers

Local EPrints ID: 434357
URI: http://eprints.soton.ac.uk/id/eprint/434357
ISSN: 0360-4012
PURE UUID: ee5bd986-3b6f-487c-b799-d067a211ab8c
ORCID for Tracey Newman: ORCID iD orcid.org/0000-0002-3727-9258

Catalogue record

Date deposited: 20 Sep 2019 16:30
Last modified: 26 Nov 2021 06:52

Export record

Altmetrics

Contributors

Author: Shmma Quraishe
Author: Tracey Newman ORCID iD
Author: Lucy Anderson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×