Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies
Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies
Deep perforator arteriopathy (DPA) and cerebral amyloid angiopathy (CAA) are the commonest known cerebral small vessel diseases (CSVD), which cause ischaemic stroke, intracebral haemorrhage (ICH) and vascular cognitive impairment (VCI). While thus far mainly considered as separate entities, we here propose that DPA and CAA share similarities, overlap and interact, so that ‘pure’ DPA or CAA are extremes along a continuum of age-related small vessel pathologies. We suggest blood-brain barrier (BBB) breakdown, endothelial damage and impaired perivascular β-amyloid (Aβ) drainage are hallmark common mechanisms connecting DPA and CAA. We also suggest a need for new biomarkers (e.g. high-resolution imaging) to deepen understanding of the complex relationships between DPA and CAA.
blood-brain barrier, cerebral amyloid angiopathy, cerebral small vessel diseases, deep perforator arteriopathy, hypertensive arteriopathy, β-amyloid drainage
Schreiber, S.
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Wilisch-Neumann, A.
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Schreiber, F.
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Assmann, A.
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Scheumann, V.
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Perosa, V.
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Jandke, S.
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Mawrin, C.
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Carare, R. O.
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Werring, D. J.
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Schreiber, S.
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Wilisch-Neumann, A.
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Schreiber, F.
bd04e7b2-fb42-468c-a09c-11729bb0cc38
Assmann, A.
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Scheumann, V.
7d10942c-4151-47f8-a6e1-3e083c6f506e
Perosa, V.
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Jandke, S.
93edb572-ac6a-4696-9a56-e5b464bb40d5
Mawrin, C.
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Carare, R. O.
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Werring, D. J.
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Schreiber, S., Wilisch-Neumann, A., Schreiber, F., Assmann, A., Scheumann, V., Perosa, V., Jandke, S., Mawrin, C., Carare, R. O. and Werring, D. J.
(2019)
Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies.
Neuropathology and Applied Neurobiology.
(doi:10.1111/nan.12576).
Abstract
Deep perforator arteriopathy (DPA) and cerebral amyloid angiopathy (CAA) are the commonest known cerebral small vessel diseases (CSVD), which cause ischaemic stroke, intracebral haemorrhage (ICH) and vascular cognitive impairment (VCI). While thus far mainly considered as separate entities, we here propose that DPA and CAA share similarities, overlap and interact, so that ‘pure’ DPA or CAA are extremes along a continuum of age-related small vessel pathologies. We suggest blood-brain barrier (BBB) breakdown, endothelial damage and impaired perivascular β-amyloid (Aβ) drainage are hallmark common mechanisms connecting DPA and CAA. We also suggest a need for new biomarkers (e.g. high-resolution imaging) to deepen understanding of the complex relationships between DPA and CAA.
Text
Schreiber_et_al-2019-Neuropathology_and_Applied_Neurobiology
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Accepted/In Press date: 11 July 2019
e-pub ahead of print date: 6 August 2019
Keywords:
blood-brain barrier, cerebral amyloid angiopathy, cerebral small vessel diseases, deep perforator arteriopathy, hypertensive arteriopathy, β-amyloid drainage
Identifiers
Local EPrints ID: 434574
URI: http://eprints.soton.ac.uk/id/eprint/434574
ISSN: 0305-1846
PURE UUID: 7f2cc367-f431-4195-abf0-1654c231585c
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Date deposited: 02 Oct 2019 16:30
Last modified: 17 Mar 2024 02:48
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Contributors
Author:
S. Schreiber
Author:
A. Wilisch-Neumann
Author:
F. Schreiber
Author:
A. Assmann
Author:
V. Scheumann
Author:
V. Perosa
Author:
S. Jandke
Author:
C. Mawrin
Author:
D. J. Werring
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