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Contralateral inhibitory and excitatory frequency response maps in the mammalian cochlear nucleus

Contralateral inhibitory and excitatory frequency response maps in the mammalian cochlear nucleus
Contralateral inhibitory and excitatory frequency response maps in the mammalian cochlear nucleus
There is increasing evidence that the responses of single units in the mammalian cochlear nucleus can be altered by the presentation of contralateral stimuli, although the functional significance of this binaural responsiveness is unknown. To further our understanding of this phenomenon we recorded single-unit (n = 110) response maps from the cochlear nucleus (ventral and dorsal divisions) of the anaesthetized guinea pig in response to presentation of ipsilateral and contralateral pure tones. Many neurones showed no evidence of input from the contralateral ear (n = 41) but other neurones from both ventral and dorsal cochlear nucleus showed clear evidence of contralateral inhibitory input (n = 61). Inhibitory response patterns were divided into two groups. In 36 neurones, contralateral tone-evoked inhibition was closely aligned with the ipsilateral excitatory response map (± 0.33 octaves) often extending to low stimulus levels. In 25 neurones, higher threshold contralateral inhibitory responses were found, mostly centred at frequencies greater than 0.33 octaves below the ipsilateral excitation. A few neurones (n = 8) exhibited responses consistent with excitatory input from the contralateral ear, which was closely aligned with the ipsilateral excitation, and were found exclusively in the dorsal cochlear nucleus. The latency of the contralateral interaction was, on average, longer than the ipsilateral latency. Interaural level difference curves are similar to other reports from the cochlear nucleus. Our results are consistent with the idea that contralateral interactions arise from a variety of direct and indirect neuronal projections.
auditory brainstem, binaural hearing, frequency tuning, guinea pig, single neurone recording
0953-816X
2515-2529
Ingham, Neil J.
30deebff-3b47-40bc-b347-047b51c80fe3
Bleeck, Stefan
c888ccba-e64c-47bf-b8fa-a687e87ec16c
Winter, Ian M.
e169233c-fc00-44fe-a0ac-5fc998095153
Ingham, Neil J.
30deebff-3b47-40bc-b347-047b51c80fe3
Bleeck, Stefan
c888ccba-e64c-47bf-b8fa-a687e87ec16c
Winter, Ian M.
e169233c-fc00-44fe-a0ac-5fc998095153

Ingham, Neil J., Bleeck, Stefan and Winter, Ian M. (2006) Contralateral inhibitory and excitatory frequency response maps in the mammalian cochlear nucleus. European Journal of Neuroscience, 24 (9), 2515-2529. (doi:10.1111/j.1460-9568.2006.05134.x).

Record type: Article

Abstract

There is increasing evidence that the responses of single units in the mammalian cochlear nucleus can be altered by the presentation of contralateral stimuli, although the functional significance of this binaural responsiveness is unknown. To further our understanding of this phenomenon we recorded single-unit (n = 110) response maps from the cochlear nucleus (ventral and dorsal divisions) of the anaesthetized guinea pig in response to presentation of ipsilateral and contralateral pure tones. Many neurones showed no evidence of input from the contralateral ear (n = 41) but other neurones from both ventral and dorsal cochlear nucleus showed clear evidence of contralateral inhibitory input (n = 61). Inhibitory response patterns were divided into two groups. In 36 neurones, contralateral tone-evoked inhibition was closely aligned with the ipsilateral excitatory response map (± 0.33 octaves) often extending to low stimulus levels. In 25 neurones, higher threshold contralateral inhibitory responses were found, mostly centred at frequencies greater than 0.33 octaves below the ipsilateral excitation. A few neurones (n = 8) exhibited responses consistent with excitatory input from the contralateral ear, which was closely aligned with the ipsilateral excitation, and were found exclusively in the dorsal cochlear nucleus. The latency of the contralateral interaction was, on average, longer than the ipsilateral latency. Interaural level difference curves are similar to other reports from the cochlear nucleus. Our results are consistent with the idea that contralateral interactions arise from a variety of direct and indirect neuronal projections.

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More information

Published date: 2006
Keywords: auditory brainstem, binaural hearing, frequency tuning, guinea pig, single neurone recording
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 43458
URI: http://eprints.soton.ac.uk/id/eprint/43458
ISSN: 0953-816X
PURE UUID: 5909539b-cd66-4130-97f0-6fb4ff50d33d
ORCID for Stefan Bleeck: ORCID iD orcid.org/0000-0003-4378-3394

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Date deposited: 25 Jan 2007
Last modified: 17 Dec 2019 01:45

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Contributors

Author: Neil J. Ingham
Author: Stefan Bleeck ORCID iD
Author: Ian M. Winter

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