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Sarcopenia and health-related outcomes: an umbrella review of observational studies

Sarcopenia and health-related outcomes: an umbrella review of observational studies
Sarcopenia and health-related outcomes: an umbrella review of observational studies
Background The clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed to capture the scale of outcomes that have been associated with the presence of sarcopenia and systematically assess the quality, strength, and credibility of these associations using an umbrella review methodology. Methods A systematic review in several databases was carried out, until 20th February 2019. For each association, random-effects summary effect size, 95% confidence intervals (CIs), heterogeneity (I2), evidence for small-study effect, evidence for excess significance bias, and 95%-prediction intervals were estimated. We used these metrics to categorize the evidence of significant outcomes (p < 0.05) from class I (convincing) to class IV (weak), according to pre-established criteria. Results From 358 abstracts, 6 meta-analyses with 14 associations were included. Sarcopenia was associated with higher risk of other comorbidities and mortality in 11 of 14 outcomes explored. However, only 3 outcomes (i.e., association between sarcopenia and increased risk of death in community-dwelling older people [odds ratio, OR = 3.60; 95% CI 2.96–4.37; n = 14,305], disability [OR = 3.04; 95% CI 1.80–5.12; n = 8569], and falls [OR = 1.60; 95% CI 1.31–1.97; n = 12,261]) presented a highly suggestive evidence (class II). Other association was classified as having only a weak evidence. Conclusion Sarcopenia is associated with several adverse health-related outcomes in older people, and its associations with mortality, disability, and falls are supported by a highly suggestive evidence. The effect of interventions on sarcopenia to improve these outcomes needs to be investigated.
1878-7649
1-10
Veronese, Nicola
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Demurtas, Jacapo
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Soysal, Pinar
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Smith, Lee
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Torbahn, Gabriel
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Schoene, Daniel
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Schwingshackl, Lukas
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Sieber, Cornel
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Bauer, Jurgen
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Cesari, Matteo
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Bruyère, Olivier
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Reginster, Jean-Yves
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Beaudart, Charlotte
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Cruz-Jentoft, Alfonso Jose
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Cooper, Cyrus
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Petrovic, Mirko
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Maggi, Stefania
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Special Interest Group in Systematic Reviews and Meta-analyses for healthy ageing Sarcopenia and Frailty and resillience in older persons of the European Geriatric Medicine Society (EuGMS)
Veronese, Nicola
a9a97f63-a828-45a3-bae0-68182c5a44fd
Demurtas, Jacapo
fe225f5a-1399-4ab5-b6e8-3d6bb250430a
Soysal, Pinar
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Smith, Lee
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Torbahn, Gabriel
4b0251f9-eeee-41e0-9f62-636c56fa4387
Schoene, Daniel
d4eb3fd9-f7c4-4e55-87a4-607976900f65
Schwingshackl, Lukas
65953bad-8bff-4aa1-b435-be6130c6d575
Sieber, Cornel
d622aad9-3827-4e71-9e0c-821559002ce6
Bauer, Jurgen
fd455e60-c2ca-4e69-ae05-a1c4f7345982
Cesari, Matteo
7e731742-9266-4ed3-a3d9-e5c51f468808
Bruyère, Olivier
ba727e54-ca17-4fa8-be3d-4729fb4b8c0d
Reginster, Jean-Yves
08b05e27-73dd-4ce9-90e5-d64ec922147a
Beaudart, Charlotte
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Cruz-Jentoft, Alfonso Jose
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Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Petrovic, Mirko
7bbd64fb-c748-4447-b4d5-2aa77527ec12
Maggi, Stefania
57e7e62a-b7dd-4291-82e3-efc8c9a7e12a

Veronese, Nicola, Demurtas, Jacapo, Soysal, Pinar, Smith, Lee, Torbahn, Gabriel, Schoene, Daniel, Schwingshackl, Lukas, Sieber, Cornel, Bauer, Jurgen, Cesari, Matteo, Bruyère, Olivier, Reginster, Jean-Yves, Beaudart, Charlotte, Cruz-Jentoft, Alfonso Jose, Cooper, Cyrus, Petrovic, Mirko and Maggi, Stefania , Special Interest Group in Systematic Reviews and Meta-analyses for healthy ageing Sarcopenia and Frailty and resillience in older persons of the European Geriatric Medicine Society (EuGMS) (2019) Sarcopenia and health-related outcomes: an umbrella review of observational studies. European Geriatric Medicine, 1-10. (doi:10.1007/s41999-019-00233-w).

Record type: Article

Abstract

Background The clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed to capture the scale of outcomes that have been associated with the presence of sarcopenia and systematically assess the quality, strength, and credibility of these associations using an umbrella review methodology. Methods A systematic review in several databases was carried out, until 20th February 2019. For each association, random-effects summary effect size, 95% confidence intervals (CIs), heterogeneity (I2), evidence for small-study effect, evidence for excess significance bias, and 95%-prediction intervals were estimated. We used these metrics to categorize the evidence of significant outcomes (p < 0.05) from class I (convincing) to class IV (weak), according to pre-established criteria. Results From 358 abstracts, 6 meta-analyses with 14 associations were included. Sarcopenia was associated with higher risk of other comorbidities and mortality in 11 of 14 outcomes explored. However, only 3 outcomes (i.e., association between sarcopenia and increased risk of death in community-dwelling older people [odds ratio, OR = 3.60; 95% CI 2.96–4.37; n = 14,305], disability [OR = 3.04; 95% CI 1.80–5.12; n = 8569], and falls [OR = 1.60; 95% CI 1.31–1.97; n = 12,261]) presented a highly suggestive evidence (class II). Other association was classified as having only a weak evidence. Conclusion Sarcopenia is associated with several adverse health-related outcomes in older people, and its associations with mortality, disability, and falls are supported by a highly suggestive evidence. The effect of interventions on sarcopenia to improve these outcomes needs to be investigated.

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Accepted/In Press date: 23 August 2019
e-pub ahead of print date: 6 September 2019

Identifiers

Local EPrints ID: 434581
URI: http://eprints.soton.ac.uk/id/eprint/434581
ISSN: 1878-7649
PURE UUID: 0822f664-1367-4a04-aafd-b38f52a25d3b
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 02 Oct 2019 16:30
Last modified: 10 Jan 2022 05:24

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Contributors

Author: Nicola Veronese
Author: Jacapo Demurtas
Author: Pinar Soysal
Author: Lee Smith
Author: Gabriel Torbahn
Author: Daniel Schoene
Author: Lukas Schwingshackl
Author: Cornel Sieber
Author: Jurgen Bauer
Author: Matteo Cesari
Author: Olivier Bruyère
Author: Jean-Yves Reginster
Author: Charlotte Beaudart
Author: Alfonso Jose Cruz-Jentoft
Author: Cyrus Cooper ORCID iD
Author: Mirko Petrovic
Author: Stefania Maggi
Corporate Author: Special Interest Group in Systematic Reviews and Meta-analyses for healthy ageing Sarcopenia and Frailty and resillience in older persons of the European Geriatric Medicine Society (EuGMS)

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