A group sequential test for ABR detection
A group sequential test for ABR detection
Objective: To detect the auditory brainstem response (ABR) automatically using an innovative sequentially applied Hotelling’s T 2 test, with the overall goal of optimising test time whilst controlling the false-positive rate (FPR).
Design: The stage-wise critical decision boundaries for accepting or rejecting the null hypothesis were found using a new approach called the Convolutional Group Sequential Test (CGST). Specificity, sensitivity, and test time were evaluated using simulations and subject recorded data. Study sample: Data consists of click-evoked ABR threshold series from 12 normal hearing adults, and recordings of EEG background activity from 17 normal hearing adults.
Results: Reductions in mean test time of up to 40–45% were observed for the sequential test, relative to a conventional “single shot” test where the statistical test is applied to the data just once. To obtain these results, it will occasionally be necessary to run the test to a higher number of stimuli, i.e. the maximum test time needs to be increased.
Conclusions: The CGST can be used to control the specificity of a sequentially applied ABR detection method. Doing so can reduce test time, relative to the “single shot” test, when considered across a cohort of test subjects.
ABR detection, Hotelling’s T2 test, objective detection methods, Sequential testing
618-627
Chesnaye, M. A.
5f337509-3255-4322-b1bf-d4d3836b36ec
Bell, S.L.
91de0801-d2b7-44ba-8e8e-523e672aed8a
Harte, J.M.
1ed3b723-9209-4f46-911d-2f2f345e0a32
Simpson, D.M.
53674880-f381-4cc9-8505-6a97eeac3c2a
Chesnaye, M. A.
5f337509-3255-4322-b1bf-d4d3836b36ec
Bell, S.L.
91de0801-d2b7-44ba-8e8e-523e672aed8a
Harte, J.M.
1ed3b723-9209-4f46-911d-2f2f345e0a32
Simpson, D.M.
53674880-f381-4cc9-8505-6a97eeac3c2a
Chesnaye, M. A., Bell, S.L., Harte, J.M. and Simpson, D.M.
(2019)
A group sequential test for ABR detection.
International Journal of Audiology, 58 (10), .
(doi:10.1080/14992027.2019.1625486).
Abstract
Objective: To detect the auditory brainstem response (ABR) automatically using an innovative sequentially applied Hotelling’s T 2 test, with the overall goal of optimising test time whilst controlling the false-positive rate (FPR).
Design: The stage-wise critical decision boundaries for accepting or rejecting the null hypothesis were found using a new approach called the Convolutional Group Sequential Test (CGST). Specificity, sensitivity, and test time were evaluated using simulations and subject recorded data. Study sample: Data consists of click-evoked ABR threshold series from 12 normal hearing adults, and recordings of EEG background activity from 17 normal hearing adults.
Results: Reductions in mean test time of up to 40–45% were observed for the sequential test, relative to a conventional “single shot” test where the statistical test is applied to the data just once. To obtain these results, it will occasionally be necessary to run the test to a higher number of stimuli, i.e. the maximum test time needs to be increased.
Conclusions: The CGST can be used to control the specificity of a sequentially applied ABR detection method. Doing so can reduce test time, relative to the “single shot” test, when considered across a cohort of test subjects.
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ChesnayeEtAl_AGroupSequentialTestForABRDetection
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Accepted/In Press date: 22 May 2019
e-pub ahead of print date: 1 July 2019
Keywords:
ABR detection, Hotelling’s T2 test, objective detection methods, Sequential testing
Identifiers
Local EPrints ID: 434598
URI: http://eprints.soton.ac.uk/id/eprint/434598
ISSN: 1499-2027
PURE UUID: e917ff97-ea98-4c8c-91e2-a27d6c8bef93
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Date deposited: 02 Oct 2019 16:30
Last modified: 16 Mar 2024 08:04
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Author:
M. A. Chesnaye
Author:
J.M. Harte
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