READ ME File For 'Data - Enhanced flow-motion complexity of skin microvascular perfusion in Sherpas and lowlanders during ascent to altitude'

Dataset DOI: 10.5258/SOTON/D1076

ReadMe Author: Andrew Chipperfield, University of Southampton [https://orcid.org/0000-0002-3026-9890]

This dataset supports the publication:
AUTHORS: Deborah Carey, Marjola Thanaj, Thomas Davies, Edward Gilbert-Kawai, Kay Mitchell, Denny Z. H. Levett3, Michael G. Mythen, Daniel S. Martin, Michael P. Grocott, Andrew J. Chipperfield, Geraldine F. Clough
TITLE: Enhanced flow-motion complexity of skin microvascular perfusion in Sherpas and lowlanders during ascent to altitude
JOURNAL: Scientific reports
PAPER DOI IF KNOWN: not yet known


This dataset contains:
Date used in the preparation of the paper and the results of analysis

The figures are as follows:

Figure 1. Examples of (A) skin BF and oxyHb signals from the forearm and (B) skin BF signals from finger measured in the time domain of an individual lowlander and Sherpa highlander at baseline (BL, black) and Everest base camp (EBC, 5300 m, blue).

Figure 2. Lempel-Ziv complexity (LZC) of skin BF signal measured over 15 epochs at the finger and forearm at baseline (BL, black) and Everest base camp (EBC, 5300 m, blue). Mean data (±SEM) are shown as solid lines for n=32 lowlanders and n=46 Sherpa highlanders. Significant difference between groups, *p<0.05, +p<0.001

Figure 3. Lempel-Ziv complexity (LZC) index of skin BF signals measured at the forearm and finger in n=32 lowlanders and n=46 Sherpa highlanders at baseline (BL, black) and Everest base camp (EBC, 5300 m, blue). Data are median and 95%CI. LZC index (mean LZC of 15 epochs) of the BF signal in both the forearm and finger microvascular beds was significantly influenced by group (forearm: p=0.0001, F=15.6; finger: p<0.0001, F=59.9), and site (forearm: p=0.0013, F=10.7; finger p=0.0025, F=9.5). ns not significant, *p =0.0003, **p<0.0001

Figure 4. Lempel-Ziv complexity (LZC) index of skin oxyHb signals measured at the forearm in n=32 lowlanders and n=46 Sherpa highlanders at baseline (BL, black) and Everest base camp (EBC, 5300 m, blue). Data are median and 95%CI. There was no significant difference between groups.

Figure 5. Multiscale Lempel-Ziv complexity (MLZC) measured between scales t = 1-12 of skin BF signal at baseline (BL, black) and Everest base camp (EBC, 5300 m, blue).at the forearm and finger at baseline (BL, black) and Everest base camp (EBC, 5300 m, blue). Data are mean ± SEM of n=32 lowlanders and n=46 Sherpa highlanders. Significant difference between groups, *p<0.05, +p<0.001

Figure 6. Spearman correlations between the flow-motion spectral power bands corresponding to endothelial (0.0095-0.02Hz) (black), neurogenic (0.02-0.06Hz) (green), myogenic (0.06-0.15Hz) (purple), respiratory (0.15-0.4Hz) (blue), and cardiac (0.4-1.6Hz) (red) activity and multiscale Lempel-Ziv complexity (MLZC) of the (A) forearm and (B) finger skin blood flow signals in n=32 lowlanders and n=46 Sherpa highlanders at baseline (BL) and Everest base camp (EBC, 5300 m). Effective sampling rate = 40Hz/scale. *p<0.05, +p<0.01.


Date of data collection: 2013

Information about geographic location of data collection: London and nepal

Licence: CC BY NC

Related projects:
None


Date that the file was created: September 2019