Hedgehog activation in CLL
Hedgehog activation in CLL
In this issue of Blood, Ghia et al observe that a proportion of patients with chronic lymphocytic leukemia (CLL) harbor mutations in genes involved in the Hedgehog (Hh) pathway resulting in expression of glioma-associated oncogene homolog 1 (GLI1). They also find that GLI1 is expressed in CLL cells without evidence of Hh mutations and that the high GLI1 levels correlate with disease progression.
2628-2630
Chiodin, Giorgia
4b3e9525-b377-4d16-b69a-e05d2e7854fe
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
20 June 2019
Chiodin, Giorgia
4b3e9525-b377-4d16-b69a-e05d2e7854fe
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Abstract
In this issue of Blood, Ghia et al observe that a proportion of patients with chronic lymphocytic leukemia (CLL) harbor mutations in genes involved in the Hedgehog (Hh) pathway resulting in expression of glioma-associated oncogene homolog 1 (GLI1). They also find that GLI1 is expressed in CLL cells without evidence of Hh mutations and that the high GLI1 levels correlate with disease progression.
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Accepted/In Press date: 1 April 2016
e-pub ahead of print date: 20 June 2019
Published date: 20 June 2019
Identifiers
Local EPrints ID: 434686
URI: http://eprints.soton.ac.uk/id/eprint/434686
ISSN: 0006-4971
PURE UUID: 34f64fb4-b3c0-4bd2-b444-8f51c80dfbaa
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Date deposited: 04 Oct 2019 16:30
Last modified: 16 Mar 2024 04:09
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Author:
Giorgia Chiodin
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