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Hedgehog activation in CLL

Hedgehog activation in CLL
Hedgehog activation in CLL

In this issue of Blood, Ghia et al observe that a proportion of patients with chronic lymphocytic leukemia (CLL) harbor mutations in genes involved in the Hedgehog (Hh) pathway resulting in expression of glioma-associated oncogene homolog 1 (GLI1). They also find that GLI1 is expressed in CLL cells without evidence of Hh mutations and that the high GLI1 levels correlate with disease progression.

0006-4971
2628-2630
Chiodin, Giorgia
4b3e9525-b377-4d16-b69a-e05d2e7854fe
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Chiodin, Giorgia
4b3e9525-b377-4d16-b69a-e05d2e7854fe
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8

Chiodin, Giorgia and Forconi, Francesco (2019) Hedgehog activation in CLL. Blood, 133 (25), 2628-2630. (doi:10.1182/blood-2019-04-901165).

Record type: Review

Abstract

In this issue of Blood, Ghia et al observe that a proportion of patients with chronic lymphocytic leukemia (CLL) harbor mutations in genes involved in the Hedgehog (Hh) pathway resulting in expression of glioma-associated oncogene homolog 1 (GLI1). They also find that GLI1 is expressed in CLL cells without evidence of Hh mutations and that the high GLI1 levels correlate with disease progression.

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More information

Accepted/In Press date: 1 April 2016
e-pub ahead of print date: 20 June 2019
Published date: 20 June 2019

Identifiers

Local EPrints ID: 434686
URI: http://eprints.soton.ac.uk/id/eprint/434686
ISSN: 0006-4971
PURE UUID: 34f64fb4-b3c0-4bd2-b444-8f51c80dfbaa

Catalogue record

Date deposited: 04 Oct 2019 16:30
Last modified: 09 Nov 2021 15:50

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Contributors

Author: Giorgia Chiodin

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