Nanoscale hybrid coating enables multifunctional tissue scaffold for potential multimodal therapeutic applications
Nanoscale hybrid coating enables multifunctional tissue scaffold for potential multimodal therapeutic applications
Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.
27269-27278
Hamilton, Andrew
9088cf01-8d7f-45f0-af56-b4784227447c
31 July 2019
Hamilton, Andrew
9088cf01-8d7f-45f0-af56-b4784227447c
Hamilton, Andrew
(2019)
Nanoscale hybrid coating enables multifunctional tissue scaffold for potential multimodal therapeutic applications.
ACS Applied Materials and Interfaces, 11 (30), .
(doi:10.1021/acsami.9b04278).
Abstract
Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.
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Accepted/In Press date: 19 June 2019
e-pub ahead of print date: 19 June 2019
Published date: 31 July 2019
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Local EPrints ID: 434695
URI: http://eprints.soton.ac.uk/id/eprint/434695
ISSN: 1944-8244
PURE UUID: ffeefb60-a186-4a05-aefe-8be4d4bbe01e
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Date deposited: 04 Oct 2019 16:30
Last modified: 16 Mar 2024 07:59
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