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Glaucoma following cataract surgery in the first two years of life: frequency, risk factors and outcomes from IoLunder2

Glaucoma following cataract surgery in the first two years of life: frequency, risk factors and outcomes from IoLunder2
Glaucoma following cataract surgery in the first two years of life: frequency, risk factors and outcomes from IoLunder2
Background: we investigated glaucoma related adverse events, predictors and impact at five years following surgery in the IoLunder2 cohort
Methods: population based observational cohort study of children undergoing cataract surgery aged 2 years or under between January 2009 to December 2010. Glaucoma was defined using internationally accepted taxonomies based on the consequences of elevated intraocular pressure. Glaucoma related adverse events were any involving elevated intraocular pressure. Multivariable analysis was undertaken to investigate potential predictors of secondary glaucoma with adjustment for within-child correlation in bilateral cataract. Unilateral and bilateral cataract were analysed separately.
Results: complete follow-up data were available for 235of 254, 93% of the inception cohort. By five years after primary cataract surgery, 20% of children with bilateral cataract and 12% with unilateral had developed secondary glaucoma. Glaucoma related complications had been diagnosed in 24% and 36% of children, respectively. Independent predictors of glaucoma were younger age at surgery (adjusted odds ratio for reduction of week in age:1.1, 95%CI 1.1–1.2, p<0.001); the presence of significant ocular comorbidity (adjOR3.2, 95%CI 1.1–9.6, p=0.01); and shorter axial length (adj OR for each mm 1.7, 95% CI 10.0–1, p=0.05) for bilateral cataract. Shorter axial length was the single independent factor in unilateral disease (adjOR9.6, 95% CI 1.7–52, p=0.009)
Conclusions: both younger age at surgery (the strongest marker of ocular ‘immaturity’) and smaller ocular size (a marker of both immaturity and developmental vulnerability) can be used to identify those at greatest risk of glaucoma due to early life cataract surgery.
0007-1161
Self, James
0f6efc58-ae24-4667-b8d6-6fafa849e389
Solebo, Ameenat Lola
98cb1481-0fa5-487c-bb8b-73d77e2a38fb
Rahi, Jugnoo
ab18043e-5f0b-49d9-a55c-51b8f45d61ba
British Isles Congenital Cataract Interest Group (BCCIG)
Self, James
0f6efc58-ae24-4667-b8d6-6fafa849e389
Solebo, Ameenat Lola
98cb1481-0fa5-487c-bb8b-73d77e2a38fb
Rahi, Jugnoo
ab18043e-5f0b-49d9-a55c-51b8f45d61ba

Solebo, Ameenat Lola and Rahi, Jugnoo , British Isles Congenital Cataract Interest Group (BCCIG) (2019) Glaucoma following cataract surgery in the first two years of life: frequency, risk factors and outcomes from IoLunder2. British Journal of Ophthalmology. (doi:10.1136/bjophthalmol-2019-314804). (In Press)

Record type: Article

Abstract

Background: we investigated glaucoma related adverse events, predictors and impact at five years following surgery in the IoLunder2 cohort
Methods: population based observational cohort study of children undergoing cataract surgery aged 2 years or under between January 2009 to December 2010. Glaucoma was defined using internationally accepted taxonomies based on the consequences of elevated intraocular pressure. Glaucoma related adverse events were any involving elevated intraocular pressure. Multivariable analysis was undertaken to investigate potential predictors of secondary glaucoma with adjustment for within-child correlation in bilateral cataract. Unilateral and bilateral cataract were analysed separately.
Results: complete follow-up data were available for 235of 254, 93% of the inception cohort. By five years after primary cataract surgery, 20% of children with bilateral cataract and 12% with unilateral had developed secondary glaucoma. Glaucoma related complications had been diagnosed in 24% and 36% of children, respectively. Independent predictors of glaucoma were younger age at surgery (adjusted odds ratio for reduction of week in age:1.1, 95%CI 1.1–1.2, p<0.001); the presence of significant ocular comorbidity (adjOR3.2, 95%CI 1.1–9.6, p=0.01); and shorter axial length (adj OR for each mm 1.7, 95% CI 10.0–1, p=0.05) for bilateral cataract. Shorter axial length was the single independent factor in unilateral disease (adjOR9.6, 95% CI 1.7–52, p=0.009)
Conclusions: both younger age at surgery (the strongest marker of ocular ‘immaturity’) and smaller ocular size (a marker of both immaturity and developmental vulnerability) can be used to identify those at greatest risk of glaucoma due to early life cataract surgery.

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Accepted/In Press date: 2 October 2019

Identifiers

Local EPrints ID: 434737
URI: http://eprints.soton.ac.uk/id/eprint/434737
ISSN: 0007-1161
PURE UUID: efe5c514-118f-4059-a049-b2a576c79376
ORCID for James Self: ORCID iD orcid.org/0000-0002-1030-9963

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Date deposited: 08 Oct 2019 16:30
Last modified: 17 Mar 2024 03:04

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Contributors

Author: James Self ORCID iD
Author: Ameenat Lola Solebo
Author: Jugnoo Rahi
Corporate Author: British Isles Congenital Cataract Interest Group (BCCIG)

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