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Combining DC and AC electric fields with Deterministic Lateral Displacement for Micro- and Nano-particle separation

Combining DC and AC electric fields with Deterministic Lateral Displacement for Micro- and Nano-particle separation
Combining DC and AC electric fields with Deterministic Lateral Displacement for Micro- and Nano-particle separation
This paper describes the behaviour of particles in a Deterministic Lateral Displacement (DLD) separation device with DC and AC electric fields applied orthogonal to the fluid flow. As a proof of principle, we demonstrate tunable micro- and nano- particle separation and fractionation depending on both particle size and zeta potential. DLD is a microfluidic technique that performs size-based binary separation of particles in a continuous flow. Here, we explore how the application of both DC and AC electric fields (separate or together) can be used to improve separation in a DLD device. We show that particles significantly smaller than the critical diameter of the device can be efficiently separated by applying orthogonal electric fields. Following the application of a DC voltage, Faradaic processes at the electrodes cause local changes in medium conductivity. This conductivity change creates an electric field gradient across the channel that results in a non-uniform electrophoretic velocity orthogonal to the primary flow direction. This phenomenon causes particles to focus into tight bands as they flow along the channel countering the effect of particle diffusion. It is shown that the final lateral displacement of particles depends on both particle size and zeta potential. Experiments with six different types of negatively charged particles and five different sizes (from 100 nm to 3 μm) and different zeta potential demonstrate how a DC electric field combined with AC electric fields (that causes negative-dielectrophoresis particle deviation) could be used for fractionation of particles on the nano-scale in micro-scale devices.
1932-1058
Calero Martin, Victor
a979e99e-b007-4e9e-ab19-11136ad76ed6
Garcia-Sanchez, Pablo
ad9ef043-1a93-41bb-9082-961e767024bc
Ramos, Antonio
79d60433-0c6b-4eaa-80ac-e2f61e704f72
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Calero Martin, Victor
a979e99e-b007-4e9e-ab19-11136ad76ed6
Garcia-Sanchez, Pablo
ad9ef043-1a93-41bb-9082-961e767024bc
Ramos, Antonio
79d60433-0c6b-4eaa-80ac-e2f61e704f72
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Calero Martin, Victor, Garcia-Sanchez, Pablo, Ramos, Antonio and Morgan, Hywel (2019) Combining DC and AC electric fields with Deterministic Lateral Displacement for Micro- and Nano-particle separation. Biomicrofluidics, 13, [054110]. (doi:10.1063/1.5124475).

Record type: Article

Abstract

This paper describes the behaviour of particles in a Deterministic Lateral Displacement (DLD) separation device with DC and AC electric fields applied orthogonal to the fluid flow. As a proof of principle, we demonstrate tunable micro- and nano- particle separation and fractionation depending on both particle size and zeta potential. DLD is a microfluidic technique that performs size-based binary separation of particles in a continuous flow. Here, we explore how the application of both DC and AC electric fields (separate or together) can be used to improve separation in a DLD device. We show that particles significantly smaller than the critical diameter of the device can be efficiently separated by applying orthogonal electric fields. Following the application of a DC voltage, Faradaic processes at the electrodes cause local changes in medium conductivity. This conductivity change creates an electric field gradient across the channel that results in a non-uniform electrophoretic velocity orthogonal to the primary flow direction. This phenomenon causes particles to focus into tight bands as they flow along the channel countering the effect of particle diffusion. It is shown that the final lateral displacement of particles depends on both particle size and zeta potential. Experiments with six different types of negatively charged particles and five different sizes (from 100 nm to 3 μm) and different zeta potential demonstrate how a DC electric field combined with AC electric fields (that causes negative-dielectrophoresis particle deviation) could be used for fractionation of particles on the nano-scale in micro-scale devices.

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Accepted/In Press date: 10 October 2019
e-pub ahead of print date: 23 October 2019

Identifiers

Local EPrints ID: 434821
URI: http://eprints.soton.ac.uk/id/eprint/434821
ISSN: 1932-1058
PURE UUID: 00578b38-6f6c-4669-aa0c-f922b35e8d48
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

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Date deposited: 11 Oct 2019 16:30
Last modified: 07 Oct 2020 01:49

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Contributors

Author: Victor Calero Martin
Author: Pablo Garcia-Sanchez
Author: Antonio Ramos
Author: Hywel Morgan ORCID iD

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