The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Design of surface-modified electrodes for the electrochemical adsorption of Platinum-based anticancer drugs

Design of surface-modified electrodes for the electrochemical adsorption of Platinum-based anticancer drugs
Design of surface-modified electrodes for the electrochemical adsorption of Platinum-based anticancer drugs
The design of a hemofiltration method that minimizes the side effects produced by the accumulation of Pt-based drugs such as cisplatin represents an important technology for cancer treatment. This work establishes the foundation for the development of an efficient platform for the electrochemical hemofiltration and simultaneous sensing of antitumor drugs, such as cisplatin and carboplatin, from physiological medium. The electrochemical filtration system is based on a gold surface-modified electrode using tris(carboxyethyl)phosphine ligands as scavengers of the Pt-based drug complexes. The platinum–phosphine interaction is shown to be more time efficient, as compared to the naturally occurring form of a glutathione–platinum adduct, and displayed a highly cooperative nature of binding. Altogether, we demonstrate that the presence of ligands capable of binding to Pt results in a differential spectroscopic and electrochemical response and the potential to adsorb and monitor the concentration of Pt salts in complex aqueous media.
0897-4756
8012-8018
Kolodziej, Adam
217f1e4b-678f-43f7-9f0b-1484f35e1fcd
Le Duff, Cécile S.
073e5d0c-7a19-4ec2-b3b5-4c54524d6b6f
Bergueiro, Julián
36029095-cfe6-4647-8025-76cd6ff27e32
Walker, Marc
47001283-be54-46a8-91ce-16fff6a064e4
Keeler, Alexander
a09b190d-f7be-4879-938d-05bea9799287
Russell, Andrea E.
b6b7c748-efc1-4d5d-8a7a-8e4b69396169
Fernández-Trillo, Paco
519b6c44-314e-4657-a7e0-2e6426296a04
Rodriguez, Paramaconi
5a751a4e-490e-42bb-9c22-7b0fc72e9a09
Kolodziej, Adam
217f1e4b-678f-43f7-9f0b-1484f35e1fcd
Le Duff, Cécile S.
073e5d0c-7a19-4ec2-b3b5-4c54524d6b6f
Bergueiro, Julián
36029095-cfe6-4647-8025-76cd6ff27e32
Walker, Marc
47001283-be54-46a8-91ce-16fff6a064e4
Keeler, Alexander
a09b190d-f7be-4879-938d-05bea9799287
Russell, Andrea E.
b6b7c748-efc1-4d5d-8a7a-8e4b69396169
Fernández-Trillo, Paco
519b6c44-314e-4657-a7e0-2e6426296a04
Rodriguez, Paramaconi
5a751a4e-490e-42bb-9c22-7b0fc72e9a09

Kolodziej, Adam, Le Duff, Cécile S., Bergueiro, Julián, Walker, Marc, Keeler, Alexander, Russell, Andrea E., Fernández-Trillo, Paco and Rodriguez, Paramaconi (2019) Design of surface-modified electrodes for the electrochemical adsorption of Platinum-based anticancer drugs. Chemistry of Materials, 31 (19), 8012-8018. (doi:10.1021/acs.chemmater.9b02382).

Record type: Article

Abstract

The design of a hemofiltration method that minimizes the side effects produced by the accumulation of Pt-based drugs such as cisplatin represents an important technology for cancer treatment. This work establishes the foundation for the development of an efficient platform for the electrochemical hemofiltration and simultaneous sensing of antitumor drugs, such as cisplatin and carboplatin, from physiological medium. The electrochemical filtration system is based on a gold surface-modified electrode using tris(carboxyethyl)phosphine ligands as scavengers of the Pt-based drug complexes. The platinum–phosphine interaction is shown to be more time efficient, as compared to the naturally occurring form of a glutathione–platinum adduct, and displayed a highly cooperative nature of binding. Altogether, we demonstrate that the presence of ligands capable of binding to Pt results in a differential spectroscopic and electrochemical response and the potential to adsorb and monitor the concentration of Pt salts in complex aqueous media.

Text
ElectroPBDs_vf_accepted - Accepted Manuscript
Download (935kB)
Text
ElectroPBDs_SI_vf_accepted
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 30 August 2019
e-pub ahead of print date: 30 August 2019
Published date: 8 October 2019

Identifiers

Local EPrints ID: 434905
URI: http://eprints.soton.ac.uk/id/eprint/434905
ISSN: 0897-4756
PURE UUID: ee273486-3e83-4131-814a-f2efdc65fcab
ORCID for Andrea E. Russell: ORCID iD orcid.org/0000-0002-8382-6443

Catalogue record

Date deposited: 15 Oct 2019 16:30
Last modified: 22 Nov 2021 07:44

Export record

Altmetrics

Contributors

Author: Adam Kolodziej
Author: Cécile S. Le Duff
Author: Julián Bergueiro
Author: Marc Walker
Author: Alexander Keeler
Author: Paco Fernández-Trillo
Author: Paramaconi Rodriguez

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×