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HEART UK consensus statement on Lipoprotein(a): a call to action

HEART UK consensus statement on Lipoprotein(a): a call to action
HEART UK consensus statement on Lipoprotein(a): a call to action
Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is an independent cardiovascular disease (CVD) risk factor, provides recommendations for its measurement in clinical practice and reviews current and emerging therapeutic strategies to reduce CVD risk. Ten statements summarise the most salient points for practitioners and patients with high Lp(a). HEART UK recommends that Lp(a) is measured in adults as follows: 1) those with a personal or family history of premature atherosclerotic CVD; 2) those with first-degree relatives who have Lp(a) levels >200 nmol/l; 3) patients with familial hypercholesterolemia; 4) patients with calcific aortic valve stenosis and 5) those with borderline (but <15%) 10-year risk of a cardiovascular event. The management of patients with raised Lp(a) levels should include: 1) reducing overall atherosclerotic risk; 2) controlling dyslipidemia with a desirable non-HDL-cholesterol level of <100 mg/dl (2.5 mmol/l) and 3) consideration of lipoprotein apheresis.
0021-9150
62-70
Cegla, Jaimini
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Neely, R Dermot G
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France, Michael
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Ferns, Gordon
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Byrne, Christopher
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Halcox, Julian
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Datta, Dev
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Capps, Nigel
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Shoulders, Carol
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Qureshi, Nadeem
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Rees, Alan
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Main, Linda
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Cramb, Robert
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Viljoen, Adie
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Payne, Jules
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Soran, Handrean
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Cegla, Jaimini
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Neely, R Dermot G
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France, Michael
617e6c40-86ef-4c79-851a-7c0c6719f27c
Ferns, Gordon
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Byrne, Christopher
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Halcox, Julian
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Datta, Dev
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Capps, Nigel
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Shoulders, Carol
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Qureshi, Nadeem
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Rees, Alan
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Main, Linda
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Cramb, Robert
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Viljoen, Adie
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Payne, Jules
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Soran, Handrean
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Cegla, Jaimini, Neely, R Dermot G, France, Michael, Ferns, Gordon, Byrne, Christopher, Halcox, Julian, Datta, Dev, Capps, Nigel, Shoulders, Carol, Qureshi, Nadeem, Rees, Alan, Main, Linda, Cramb, Robert, Viljoen, Adie, Payne, Jules and Soran, Handrean (2019) HEART UK consensus statement on Lipoprotein(a): a call to action. Atherosclerosis, 291, 62-70. (doi:10.1016/j.atherosclerosis.2019.10.011).

Record type: Article

Abstract

Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is an independent cardiovascular disease (CVD) risk factor, provides recommendations for its measurement in clinical practice and reviews current and emerging therapeutic strategies to reduce CVD risk. Ten statements summarise the most salient points for practitioners and patients with high Lp(a). HEART UK recommends that Lp(a) is measured in adults as follows: 1) those with a personal or family history of premature atherosclerotic CVD; 2) those with first-degree relatives who have Lp(a) levels >200 nmol/l; 3) patients with familial hypercholesterolemia; 4) patients with calcific aortic valve stenosis and 5) those with borderline (but <15%) 10-year risk of a cardiovascular event. The management of patients with raised Lp(a) levels should include: 1) reducing overall atherosclerotic risk; 2) controlling dyslipidemia with a desirable non-HDL-cholesterol level of <100 mg/dl (2.5 mmol/l) and 3) consideration of lipoprotein apheresis.

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FINAL Lipoprotein(a) HeartUK statement - Accepted Manuscript
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Accepted/In Press date: 10 October 2019
e-pub ahead of print date: 14 October 2019
Published date: December 2019

Identifiers

Local EPrints ID: 434922
URI: http://eprints.soton.ac.uk/id/eprint/434922
ISSN: 0021-9150
PURE UUID: b51ae52d-8f45-4d06-afb0-d1a666c70be3
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 16 Oct 2019 16:30
Last modified: 17 Mar 2024 02:49

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Contributors

Author: Jaimini Cegla
Author: R Dermot G Neely
Author: Michael France
Author: Gordon Ferns
Author: Julian Halcox
Author: Dev Datta
Author: Nigel Capps
Author: Carol Shoulders
Author: Nadeem Qureshi
Author: Alan Rees
Author: Linda Main
Author: Robert Cramb
Author: Adie Viljoen
Author: Jules Payne
Author: Handrean Soran

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