Enantioselective synthesis of alkyl azaarenes
Enantioselective synthesis of alkyl azaarenes
This Minireview covers reports on the enantioselective synthesis of alkyl azaarenes since 2014. It deals with the latest achievements on the reactivity of alkyl azaarenes aiming at the preparation of more complex azaarenes containing chiral centers. They rely on the activating properties of the nitrogen atom when opportunely coordinated with a metal complex or Brønsted acid and possibly containing chiral ligands. In addition, conveniently located electron-withdrawing activating functional groups help increase the reactivity of the azaarenes. The same concepts operate in the case of vinyl azaarenes.
azaarenes, diastereoselectivity, enantioselectivity, pyridines, quinolines
Meazza, Marta
c4665645-8c77-4cfd-aa02-6bcc3341c1aa
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Meazza, Marta
c4665645-8c77-4cfd-aa02-6bcc3341c1aa
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Meazza, Marta and Rios, Ramon
(2019)
Enantioselective synthesis of alkyl azaarenes.
Asian Journal of Organic Chemistry.
(doi:10.1002/ajoc.201900363).
Abstract
This Minireview covers reports on the enantioselective synthesis of alkyl azaarenes since 2014. It deals with the latest achievements on the reactivity of alkyl azaarenes aiming at the preparation of more complex azaarenes containing chiral centers. They rely on the activating properties of the nitrogen atom when opportunely coordinated with a metal complex or Brønsted acid and possibly containing chiral ligands. In addition, conveniently located electron-withdrawing activating functional groups help increase the reactivity of the azaarenes. The same concepts operate in the case of vinyl azaarenes.
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e-pub ahead of print date: 31 July 2019
Keywords:
azaarenes, diastereoselectivity, enantioselectivity, pyridines, quinolines
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Local EPrints ID: 435065
URI: http://eprints.soton.ac.uk/id/eprint/435065
ISSN: 2193-5807
PURE UUID: 56add2e9-e29b-4939-8de8-261823764e10
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Date deposited: 21 Oct 2019 16:30
Last modified: 16 Mar 2024 04:13
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Author:
Marta Meazza
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