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Top research priorities in healthcare-associated infection in the UK

Top research priorities in healthcare-associated infection in the UK
Top research priorities in healthcare-associated infection in the UK

Background: There is a mismatch between research questions which are considered to be important by patients, carers and healthcare professionals and the research performed in many fields of medicine. No relevant studies which have assessed research priorities in healthcare-associated infection (HCAI) that have involved patients' and carers' opinions were identified in the literature. Aim: The Healthcare-Associated Infections Priority Setting Partnership was established to identify the top research priorities in the prevention, diagnosis and treatment of HCAI in the UK, considering the opinions of all these groups. Methods: The methods broadly followed the principles of the James Lind Alliance (JLA) priority setting activity. Findings: In total, 259 unique valid research questions were identified from 221 valid responses to a consultation of patients, carers and healthcare professionals after seeking their opinions for research priorities. The steering committee of the priority setting partnership rationalized these to 50 unique questions. A literature review established that for these questions there were no recent high-quality systematic reviews, high-quality systematic reviews which concluded that further studies were necessary, or the steering committee considered that further research was required despite the conclusions of recent systematic reviews. An interim survey ranked the 50 questions, and the 10 main research priorities were identified from the top 32 questions by consensus at a final priority setting workshop of patients, carers and healthcare professionals using group discussions. Conclusions: A priority setting process using JLA methods and principles involving patients, carers and healthcare professionals was used to identify the top 10 priority areas for research related to HCAI. Basic, translational, clinical and public health research would be required to address these uncertainties.

Antibiotic resistance, Antimicrobial resistance, Healthcare-associated infections, Point-of-care testing, Research priorities
0195-6701
Wilson, P.
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Gurusamy, K. S.
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Morley, R.
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Whiting, C.
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Maeso, B.
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FitzGerald, G.
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Bennett, S.
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Bostock, J.
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Brealey, D.
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Cann, M.
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Kiernan, M.
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Leaper, D.
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Moore, M.
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Oppenheim, B.
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Thompson, P.
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Tingle, A.
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Wilson, P.
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Gurusamy, K. S.
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Morley, R.
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Whiting, C.
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Maeso, B.
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FitzGerald, G.
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Bennett, S.
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Bostock, J.
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Brealey, D.
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Cann, M.
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Kiernan, M.
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Leaper, D.
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Moore, M.
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Oppenheim, B.
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Thompson, P.
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Tingle, A.
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Wilson, P., Gurusamy, K. S., Morley, R., Whiting, C., Maeso, B., FitzGerald, G., Bennett, S., Bostock, J., Brealey, D., Cann, M., Kiernan, M., Leaper, D., Moore, M., Oppenheim, B., Thompson, P. and Tingle, A. (2019) Top research priorities in healthcare-associated infection in the UK. Journal of Hospital Infection. (doi:10.1016/j.jhin.2019.08.013).

Record type: Article

Abstract

Background: There is a mismatch between research questions which are considered to be important by patients, carers and healthcare professionals and the research performed in many fields of medicine. No relevant studies which have assessed research priorities in healthcare-associated infection (HCAI) that have involved patients' and carers' opinions were identified in the literature. Aim: The Healthcare-Associated Infections Priority Setting Partnership was established to identify the top research priorities in the prevention, diagnosis and treatment of HCAI in the UK, considering the opinions of all these groups. Methods: The methods broadly followed the principles of the James Lind Alliance (JLA) priority setting activity. Findings: In total, 259 unique valid research questions were identified from 221 valid responses to a consultation of patients, carers and healthcare professionals after seeking their opinions for research priorities. The steering committee of the priority setting partnership rationalized these to 50 unique questions. A literature review established that for these questions there were no recent high-quality systematic reviews, high-quality systematic reviews which concluded that further studies were necessary, or the steering committee considered that further research was required despite the conclusions of recent systematic reviews. An interim survey ranked the 50 questions, and the 10 main research priorities were identified from the top 32 questions by consensus at a final priority setting workshop of patients, carers and healthcare professionals using group discussions. Conclusions: A priority setting process using JLA methods and principles involving patients, carers and healthcare professionals was used to identify the top 10 priority areas for research related to HCAI. Basic, translational, clinical and public health research would be required to address these uncertainties.

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JLA170719v3i - Accepted Manuscript
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Accepted/In Press date: 13 August 2019
e-pub ahead of print date: 17 August 2019
Keywords: Antibiotic resistance, Antimicrobial resistance, Healthcare-associated infections, Point-of-care testing, Research priorities

Identifiers

Local EPrints ID: 435292
URI: http://eprints.soton.ac.uk/id/eprint/435292
ISSN: 0195-6701
PURE UUID: 6868f634-2b5f-4bc3-94e8-f0bc4b30c4dd
ORCID for M. Moore: ORCID iD orcid.org/0000-0002-5127-4509

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Date deposited: 30 Oct 2019 17:30
Last modified: 09 Jan 2022 07:32

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Contributors

Author: P. Wilson
Author: K. S. Gurusamy
Author: R. Morley
Author: C. Whiting
Author: B. Maeso
Author: G. FitzGerald
Author: S. Bennett
Author: J. Bostock
Author: D. Brealey
Author: M. Cann
Author: M. Kiernan
Author: D. Leaper
Author: M. Moore ORCID iD
Author: B. Oppenheim
Author: P. Thompson
Author: A. Tingle

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