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6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine

6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine
6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine
We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with 1H/13C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS).
2-methyl-2H-1,2,3-triazole, 4-anilino-quin(az)olines, conformational flexibility, hinge binder, kinase inhibitor design
1422-8599
Asquith, Christopher R.M.
0b3a8a42-97dc-415f-9ab2-45f56547625e
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Asquith, Christopher R.M.
0b3a8a42-97dc-415f-9ab2-45f56547625e
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2

Asquith, Christopher R.M. and Tizzard, Graham J. (2019) 6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine. Molbank, 2019 (4), [M1087]. (doi:10.3390/M1087).

Record type: Article

Abstract

We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with 1H/13C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS).

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Accepted/In Press date: 24 October 2019
Published date: 27 October 2019
Keywords: 2-methyl-2H-1,2,3-triazole, 4-anilino-quin(az)olines, conformational flexibility, hinge binder, kinase inhibitor design

Identifiers

Local EPrints ID: 435367
URI: http://eprints.soton.ac.uk/id/eprint/435367
ISSN: 1422-8599
PURE UUID: 09d97d8b-2b3e-4694-8e75-7e17a0143fce
ORCID for Graham J. Tizzard: ORCID iD orcid.org/0000-0002-1577-5779

Catalogue record

Date deposited: 01 Nov 2019 17:30
Last modified: 26 Nov 2021 02:45

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Contributors

Author: Christopher R.M. Asquith

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